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1JJ9

Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition

Summary for 1JJ9
Entry DOI10.2210/pdb1jj9/pdb
DescriptorMatrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywordsmmp-8, substrate recognition, cis-peptide bond, conformational transition, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasmic granule: P22894
Total number of polymer chains1
Total formula weight18654.08
Authors
Brandstetter, H.,Grams, F.,Glitz, D.,Lang, A.,Huber, R.,Bode, W.,Krell, H.-W.,Engh, R.A. (deposition date: 2001-07-04, release date: 2001-08-01, Last modification date: 2024-03-13)
Primary citationBrandstetter, H.,Grams, F.,Glitz, D.,Lang, A.,Huber, R.,Bode, W.,Krell, H.W.,Engh, R.A.
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
J.Biol.Chem., 276:17405-17412, 2001
Cited by
PubMed: 11278347
DOI: 10.1074/jbc.M007475200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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