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PDB: 22 results
4E1G
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BU of 4e1g by Molmil
X-ray crystal structure of alpha-linolenic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2012-03-06
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287, 2012
7KP4
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BU of 7kp4 by Molmil
Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain
Descriptor: Claudin-4, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2020-11-10
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
Proc.Natl.Acad.Sci.USA, 118, 2021
6OV3
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BU of 6ov3 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form
Descriptor: Claudin-9, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OV2
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BU of 6ov2 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form
Descriptor: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
8U5B
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BU of 8u5b by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1
Descriptor: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2023-09-12
Release date:2023-09-27
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
8U4V
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BU of 8u4v by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody
Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
Authors:Vecchio, A.J.
Deposit date:2023-09-11
Release date:2023-10-25
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
3MDL
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BU of 3mdl by Molmil
X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2010-03-30
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
9BEI
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BU of 9bei by Molmil
Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody
Descriptor: Anti-fab nanobody, COP-2 Fab Heavy chain, COP-2 Fab Light chain, ...
Authors:Vecchio, A.J.
Deposit date:2024-04-15
Release date:2024-04-24
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Computational design of soluble and functional membrane protein analogues.
Nature, 2024
3OLT
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BU of 3olt by Molmil
X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of R513H murine COX-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3OLU
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BU of 3olu by Molmil
X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of R513H murine COX-2
Descriptor: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
J.Biol.Chem., 286, 2011
3HS5
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BU of 3hs5 by Molmil
X-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS6
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BU of 3hs6 by Molmil
X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3HS7
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BU of 3hs7 by Molmil
X-ray crystal structure of docosahexaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
Deposit date:2009-06-10
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3KRK
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BU of 3krk by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ...
Authors:Vecchio, A.J, Simmons, D.M, Malkowski, M.G.
Deposit date:2009-11-18
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J.Biol.Chem., 285, 2010
3QH0
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BU of 3qh0 by Molmil
X-ray crystal structure of palmitic acid bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-01-25
Release date:2011-04-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer.
J.Biol.Chem., 286, 2011
3QMO
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BU of 3qmo by Molmil
X-ray crystal structure of NS-398 bound to the cyclooxygenase channel of cyclooxygenase-2
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-02-04
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of NS-398 bound to cyclooxygenase-2.
J.Struct.Biol., 176, 2011
3TZI
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BU of 3tzi by Molmil
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vecchio, A.J, Malkowski, M.G.
Deposit date:2011-09-27
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE.
J.Biol.Chem., 287, 2012
7TDM
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BU of 7tdm by Molmil
CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
Descriptor: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2022-01-01
Release date:2022-02-09
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
7TDN
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BU of 7tdn by Molmil
CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
Descriptor: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2022-01-01
Release date:2022-02-09
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
8U5F
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BU of 8u5f by Molmil
Crystal Structure of Trypsinized Clostridium perfringens Enterotoxin
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Heat-labile enterotoxin B chain, ...
Authors:Kapoor, S, Ogbu, C.P, Vecchio, A.J.
Deposit date:2023-09-12
Release date:2023-09-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023
8U5E
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BU of 8u5e by Molmil
Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 21 21 21
Descriptor: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ...
Authors:Kapoor, S, Vecchio, A.J.
Deposit date:2023-09-12
Release date:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023
8U5D
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BU of 8u5d by Molmil
Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 41 21 2
Descriptor: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ...
Authors:Kapoor, S, Vecchio, A.J.
Deposit date:2023-09-12
Release date:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin.
Toxins, 15, 2023

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