3HS6

X-ray crystal structure of eicosapentaenoic acid bound to the cyclooxygenase channel of cyclooxygenase-2

Summary for 3HS6

Entry DOI	10.2210/pdb3hs6/pdb
Related	1CVU 1DDX 1DIY 1IGX 3HS5 3HS7 5COX
Descriptor	Prostaglandin G/H synthase 2, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	oxidoreductase, dioxygenase, disulfide bond, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, heme, iron, lipid synthesis, membrane, metal-binding, microsome, peroxidase, phosphoprotein, prostaglandin biosynthesis
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	141382.53
Authors	Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. (deposition date: 2009-06-10, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citation	Vecchio, A.J.,Simmons, D.M.,Malkowski, M.G. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J.Biol.Chem., 285:22152-22163, 2010 Cited by PubMed: 20463020 DOI: 10.1074/jbc.M110.119867 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation