9BEI

Cryo-EM structure of synthetic claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-2, and Nanobody

This is a non-PDB format compatible entry.

Summary for 9BEI

• Entry DOI: 10.2210/pdb9bei/pdb
• Related: 7DTM
• EMDB information: 44479
• Descriptor: Claudin-4, Heat-labile enterotoxin B chain, COP-2 Fab Heavy chain, ... (5 entities in total)
• Functional Keywords: claudin, fab, toxin, membrane protein, membrane protein-immune sysytem complex, membrane protein/immune sysytem
• Biological source: Clostridium perfringens; More
• Total number of polymer chains: 5
• Total formula weight: 98625.79

Authors

Vecchio, A.J. (deposition date: 2024-04-15, release date: 2024-04-24, Last modification date: 2024-07-24)

• Primary citation: Goverde, C.A.,Pacesa, M.,Goldbach, N.,Dornfeld, L.J.,Balbi, P.E.M.,Georgeon, S.,Rosset, S.,Kapoor, S.,Choudhury, J.,Dauparas, J.,Schellhaas, C.,Kozlov, S.,Baker, D.,Ovchinnikov, S.,Vecchio, A.J.,Correia, B.E.; Computational design of soluble and functional membrane protein analogues.; Nature, 631:449-458, 2024; PubMed: 38898281; DOI: 10.1038/s41586-024-07601-y

Experimental method

ELECTRON MICROSCOPY (4.16 Å)