1N9A
| Farnesyltransferase complex with tetrahydropyridine inhibitors | Descriptor: | 1-{2-[3-(4-CYANO-BENZYL)-3H-IMIDAZOL-4-YL]-ACETYL}-5-NAPHTHALEN-1-YL-1,2,3,6-TETRAHYDRO-PYRIDINE-4-CARBONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ... | Authors: | Gwaltney II, S.L, O'Conner, S.J, Nelson, L.T, Sullivan, G.M, Imade, H, Wang, W, Hasvold, L, Li, Q, Cohen, J, Gu, W.Z. | Deposit date: | 2002-11-22 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. Bioorg.Med.Chem.Lett., 13, 2003
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1K3V
| Porcine Parvovirus Capsid | Descriptor: | capsid protein VP2 | Authors: | Simpson, A.A, Hebert, B, Sullivan, G.M, Parrish, C.R, Zadori, Z, Tijssen, P, Rossmann, M.G. | Deposit date: | 2001-10-04 | Release date: | 2001-10-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | The structure of porcine parvovirus: comparison with related viruses. J.Mol.Biol., 315, 2002
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1BW5
| THE NMR SOLUTION STRUCTURE OF THE HOMEODOMAIN OF THE RAT INSULIN GENE ENHANCER PROTEIN ISL-1, 50 STRUCTURES | Descriptor: | INSULIN GENE ENHANCER PROTEIN ISL-1 | Authors: | Ippel, J.H, Larsson, G, Behravan, G, Zdunek, J, Lundqvist, M, Schleucher, J, Lycksell, P.-O, Wijmenga, S.S. | Deposit date: | 1998-09-29 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the homeodomain of the rat insulin-gene enhancer protein isl-1. Comparison with other homeodomains. J.Mol.Biol., 288, 1999
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1EEM
| GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS | Descriptor: | GLUTATHIONE, GLUTATHIONE-S-TRANSFERASE, SULFATE ION | Authors: | Board, P, Coggan, M, Chelvanayagam, G, Easteal, S, Jermiin, L.S, Schulte, G.K, Danley, D.E, Hoth, L.R, Griffor, M.C, Kamath, A.V, Rosner, M.H, Chrunyk, B.A, Perregaux, D.E, Gabel, C.A, Geoghegan, K.F, Pandit, J. | Deposit date: | 2000-02-01 | Release date: | 2000-08-11 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Identification, characterization, and crystal structure of the Omega class glutathione transferases. J.Biol.Chem., 275, 2000
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4BBX
| Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia | Descriptor: | 4-[3-[1-[(2S)-2-methoxypropyl]pyrazol-4-yl]-2-methyl-imidazo[1,2-a]pyrazin-8-yl]morpholine, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ... | Authors: | Bartolome-Nebreda, J.M, Conde-Ceide, S, Delgado, F, Martin, M.L, Martinez-Viturro, C.M, Pastor, J, Tong, H.M, Iturrino, L, Macdonald, G.J, Sanderson, W, Megens, A, Langlois, X, Somers, M, Vanhoof, G. | Deposit date: | 2012-09-28 | Release date: | 2013-10-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of a Potent, Selective and Orally Active Pde10A Inhibitor for the Potential Treatment of Schizophrenia. J.Med.Chem., 57, 2014
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2WUX
| the crystal structure of recombinant baculovirus polyhedra | Descriptor: | POLYHEDRIN | Authors: | Ji, X, Sutton, G, Evans, G, Axford, D, Owen, R, Stuart, D.I. | Deposit date: | 2009-10-10 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.838 Å) | Cite: | How Baculovirus Polyhedra Fit Square Pegs Into Round Holes to Robustly Package Viruses. Embo J., 29, 2010
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5AHF
| Crystal structure of Salmonella enterica HisA D7N with ProFAR | Descriptor: | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, GLYCEROL, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Soderholm, A, Guo, X, Newton, M.S, Evans, G.B, Nasvall, J, Patrick, W.M, Selmer, M. | Deposit date: | 2015-02-05 | Release date: | 2015-09-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa J.Biol.Chem., 290, 2015
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1NW4
| Crystal Structure of Plasmodium falciparum Purine Nucleoside Phosphorylase in complex with ImmH and Sulfate | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Shi, W, Ting, L.M, Kicska, G.A, Lewandowicz, A, Tyler, P.C, Evans, G.B, Furneaux, R.H, Kim, K, Almo, S.C, Schramm, V.L. | Deposit date: | 2003-02-05 | Release date: | 2004-03-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION. J.Biol.Chem., 279, 2004
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5AHI
| Crystal structure of salmonalla enterica HisA mutant D7N with ProFAR | Descriptor: | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO) METHYLIDENE AMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE, CHLORIDE ION, GLYCEROL, ... | Authors: | Soderholm, A, Guo, X, Newton, M.S, Evans, G.B, Nasvall, J, Patrick, W.M, Selmer, M. | Deposit date: | 2015-02-06 | Release date: | 2016-03-02 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.999 Å) | Cite: | Structure and Mechanism of Hisa from Salmonella Enterica To be Published
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2WUY
| the crystal structure of wild-type baculovirus polyhedra | Descriptor: | POLYHEDRIN | Authors: | Ji, X, Sutton, G, Evans, G, Axford, D, Owen, R, Stuart, D.I. | Deposit date: | 2009-10-10 | Release date: | 2009-12-15 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | How Baculovirus Polyhedra Fit Square Pegs Into Round Holes to Robustly Package Viruses. Embo J., 29, 2010
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4ZXR
| Structure of Thaumatin wrapped in graphene within vacuum | Descriptor: | GLYCEROL, L(+)-TARTARIC ACID, Thaumatin-1 | Authors: | Aller, P, Warren, A.J, Trincao, J, Evans, G. | Deposit date: | 2015-05-20 | Release date: | 2015-10-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | In vacuo X-ray data collection from graphene-wrapped protein crystals. Acta Crystallogr.,Sect.D, 71, 2015
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1N3I
| Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH | Descriptor: | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine Nucleoside Phosphorylase | Authors: | Lewandowicz, A, Shi, W, Evans, G.B, Tyler, P.C, Furneaux, R.H, Basso, L.A, Santos, D.S, Almo, S.C, Schramm, V.L. | Deposit date: | 2002-10-28 | Release date: | 2003-09-30 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase BIOCHEMISTRY, 42, 2003
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5A5W
| Crystal structure of Salmonella enterica HisA D7N D176A with ProFAR | Descriptor: | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Soderholm, A, Guo, X, Newton, M.S, Evans, G.B, Nasvall, J, Patrick, W.M, Selmer, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa J.Biol.Chem., 290, 2015
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1CS2
| NMR STRUCTURES OF B-DNA D(CTACTGCTTTAG).D(CTAAAGCAGTAG) | Descriptor: | 5'-d(*CP*TP*AP*AP*AP*GP*CP*AP*GP*TP*AP*G)-3', 5'-d(*CP*TP*AP*CP*TP*GP*CP*TP*TP*TP*AP*G)-3' | Authors: | Leporc, S, Mauffret, O, Tevanian, G, Lescot, E, Monnot, M, Fermandjian, S. | Deposit date: | 1999-08-16 | Release date: | 1999-08-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An NMR and molecular modelling analysis of d(CTACTGCTTTAG). d(CTAAAGCAGTAG) reveals that the particular behaviour of TpA steps is related to edge-to-edge contacts of their base-pairs in the major groove Nucleic Acids Res., 27, 1999
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1Q1G
| Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H | Descriptor: | 3,4-DIHYDROXY-2-[(METHYLSULFANYL)METHYL]-5-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)PYRROLIDINIUM, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Shi, W, Ting, L.M, Kicska, G.A, Lewandowicz, A, Tyler, P.C, Evans, G.B, Furneaux, R.H, Kim, K, Almo, S.C, Schramm, V.L. | Deposit date: | 2003-07-19 | Release date: | 2004-03-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION. J.Biol.Chem., 279, 2004
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210D
| CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A)CG] AND ITS PLATINATED DERIVATIVE | Descriptor: | DNA (5'-D(*CP*GP*TP*(1AP)P*CP*G)-3'), SPERMINE | Authors: | Parkinson, G.N, Arvantis, G.M, Lessinger, L, Ginell, S.L, Jones, R, Gaffney, B, Berman, H.M. | Deposit date: | 1995-06-13 | Release date: | 1996-03-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative. Biochemistry, 34, 1995
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211D
| THE CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A) CG] AND ITS PLATINATED DERIVATIVE | Descriptor: | DNA (5'-D(*CP*GP*TP*(1AP)P*CP*(PT(NH3)3)G)-3'), PLATINUM TRIAMINE ION, SPERMINE | Authors: | Parkinson, G.N, Arvantis, G.M, Lessinger, L, Ginell, S.L, Jones, R, Gaffney, B, Berman, H.M. | Deposit date: | 1995-06-13 | Release date: | 1996-03-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative. Biochemistry, 34, 1995
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1Y6Q
| Cyrstal structure of MTA/AdoHcy nucleosidase complexed with MT-DADMe-ImmA | Descriptor: | (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL, CHLORIDE ION, MTA/SAH nucleosidase | Authors: | Lee, J.E, Singh, V, Evans, G.B, Tyler, P.C, Furneaux, R.H, Cornell, K.A, Riscoe, M.K, Schramm, V.L, Howell, P.L. | Deposit date: | 2004-12-06 | Release date: | 2005-03-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. J.Biol.Chem., 280, 2005
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1FV7
| A TWO B-Z JUNCTION CONTAINING DNA RESOLVES INTO AN ALL RIGHT HANDED DOUBLE HELIX | Descriptor: | 5'-D(*(5CM)P*GP*(5CM)P*GP*(0DC)P*(0DG)P*(5CM)P*GP*(5CM)P*G)-3' | Authors: | Mauffret, O, El Amri, C, Santamaria, F, Tevanian, G, Rayner, B, Fermandjian, S. | Deposit date: | 2000-09-19 | Release date: | 2000-10-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A two B-Z junction containing DNA resolves into an all right-handed double-helix. Nucleic Acids Res., 28, 2000
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1Y6R
| Crystal structure of MTA/AdoHcy nucleosidase complexed with MT-ImmA. | Descriptor: | (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL, MTA/SAH nucleosidase | Authors: | Lee, J.E, Singh, V, Evans, G.B, Tyler, P.C, Furneaux, R.H, Cornell, K.A, Riscoe, M.K, Schramm, V.L, Howell, P.L. | Deposit date: | 2004-12-06 | Release date: | 2005-03-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. J.Biol.Chem., 280, 2005
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1RKC
| Human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969) | Descriptor: | Talin, Vinculin | Authors: | Izard, T, Evans, G, Borgon, R.A, Rush, C.L, Bricogne, G, Bois, P.R. | Deposit date: | 2003-11-21 | Release date: | 2004-01-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Vinculin activation by talin through helical bundle conversion Nature, 427, 2004
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1RKE
| Human vinculin head (1-258) in complex with human vinculin tail (879-1066) | Descriptor: | VCL protein, Vinculin | Authors: | Izard, T, Evans, G, Borgon, R.A, Rush, C.L, Bricogne, G, Bois, P.R. | Deposit date: | 2003-11-21 | Release date: | 2004-01-13 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Vinculin activation by talin through helical bundle conversion Nature, 427, 2004
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2BP2
| THE STRUCTURE OF BOVINE PANCREATIC PROPHOSPHOLIPASE A2 AT 3.0 ANGSTROMS RESOLUTION | Descriptor: | PHOSPHOLIPASE A2 | Authors: | Dijkstra, B.W, Vannes, G.J.H, Kalk, K.H, Brandenburg, N.P, Hol, W.G.J, Drenth, J. | Deposit date: | 1981-06-05 | Release date: | 1981-07-16 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structure of Bovine Pancreatic Prophospholipase A2 at 3.0 Angstroms Resolution Acta Crystallogr.,Sect.B, 38, 1982
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4G89
| Crystal structure of k. pneumoniae mta/adohcy nucleosidase in complex with fragmented s-adenosyl-l-homocysteine | Descriptor: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ADENINE, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Norris, G.E, Brown, R.L, Anderson, B.F, Tyler, P.C, Evans, G.B. | Deposit date: | 2012-07-23 | Release date: | 2012-09-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of k. pneumoniae mta/adohcy nucleosidase in complex with fragmented s-adenosyl-l-homocysteine To be Published
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4GMH
| Crystal structure of staphylococcus aureus 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase | Descriptor: | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, ACETATE ION | Authors: | Brown, R.L, Anderson, B.F, Norris, G.E, Tyler, P.C, Evans, G.B, Sutherland-Smith, A.J. | Deposit date: | 2012-08-15 | Release date: | 2012-11-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of staphylococcus aureus 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase To be Published
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