1K3V

Porcine Parvovirus Capsid

Summary for 1K3V

• Entry DOI: 10.2210/pdb1k3v/pdb
• Related: 1dnv 1fpv 1mvm 4dpv
• Descriptor: capsid protein VP2 (1 entity in total)
• Functional Keywords: capsid, icosahadral, beta sheet, icosahedral virus, virus
• Biological source: Porcine parvovirus
• Cellular location: Virion (By similarity): P18546
• Total number of polymer chains: 1
• Total formula weight: 64411.31

Authors

Simpson, A.A.,Hebert, B.,Sullivan, G.M.,Parrish, C.R.,Zadori, Z.,Tijssen, P.,Rossmann, M.G. (deposition date: 2001-10-04, release date: 2001-10-24, Last modification date: 2024-04-03)

Primary citation

Simpson, A.A.,Hebert, B.,Sullivan, G.M.,Parrish, C.R.,Zadori, Z.,Tijssen, P.,Rossmann, M.G.
The structure of porcine parvovirus: comparison with related viruses.
J.Mol.Biol., 315:1189-1198, 2002

PubMed Abstract: The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions.

PubMed: 11827486
DOI: 10.1006/jmbi.2001.5319

Experimental method

X-RAY DIFFRACTION (3.5 Å)