5A5W

Crystal structure of Salmonella enterica HisA D7N D176A with ProFAR

Summary for 5A5W

Entry DOI	10.2210/pdb5a5w/pdb
Descriptor	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate (3 entities in total)
Functional Keywords	isomerase, histidine biosynthesis, profar
Biological source	Salmonella enterica
Cellular location	Cytoplasm: A0A630AQ07
Total number of polymer chains	1
Total formula weight	27664.26
Authors	Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M. (deposition date: 2015-06-23, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M. Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa J.Biol.Chem., 290:24657-, 2015 Cited by PubMed: 26294764 DOI: 10.1074/JBC.M115.678086 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation