6CHA
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2SPT
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1HXE
| SERINE PROTEASE | Descriptor: | HIRUDIN VARIANT-1, RUBIDIUM ION, THROMBIN | Authors: | Tulinsky, A, Zhang, E. | Deposit date: | 1995-12-07 | Release date: | 1996-11-08 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The molecular environment of the Na+ binding site of thrombin. Biophys.Chem., 63, 1997
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1HCG
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4HTC
| THE REFINED STRUCTURE OF THE HIRUDIN-THROMBIN COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ... | Authors: | Tulinsky, A, Rydel, T.J, Bode, W, Huber, R. | Deposit date: | 1993-06-25 | Release date: | 1994-01-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Refined structure of the hirudin-thrombin complex. J.Mol.Biol., 221, 1991
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3HAT
| ACTIVE SITE MIMETIC INHIBITION OF THROMBIN | Descriptor: | FPAM (FIBRINOPEPTIDE A MIMIC), Hirudin variant-2, Thrombin heavy chain, ... | Authors: | Tulinsky, A, Mathews, I.I. | Deposit date: | 1994-10-16 | Release date: | 1995-02-27 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Active-site mimetic inhibition of thrombin. Acta Crystallogr.,Sect.D, 51, 1995
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2PK4
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5HPG
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1HLT
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2HPQ
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2HPP
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3HTC
| THE STRUCTURE OF A COMPLEX OF RECOMBINANT HIRUDIN AND HUMAN ALPHA-THROMBIN | Descriptor: | ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUDIN VARIANT 2 | Authors: | Tulinsky, A, Rydel, T.J, Ravichandran, K.G, Huber, R, Bode, W. | Deposit date: | 1993-06-11 | Release date: | 1994-01-31 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of a complex of recombinant hirudin and human alpha-thrombin. Science, 249, 1990
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2HGT
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2HNT
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1KGA
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1HXF
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1PK4
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1DIT
| COMPLEX OF A DIVALENT INHIBITOR WITH THROMBIN | Descriptor: | ALPHA-THROMBIN, PEPTIDE INHIBITOR CVS995 | Authors: | Tulinsky, A, Krishnan, R. | Deposit date: | 1995-07-20 | Release date: | 1996-06-10 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic. Protein Sci., 5, 1996
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1NRQ
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1NRP
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1NRO
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1NRR
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1NRS
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1NRN
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1HAH
| THE ISOMORPHOUS STRUCTURES OF PRETHROMBIN2, HIRUGEN-AND PPACK-THROMBIN: CHANGES ACCOMPANYING ACTIVATION AND EXOSITE BINDING TO THROMBIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ... | Authors: | Tulinsky, A, Vijayalakshmi, J. | Deposit date: | 1994-06-27 | Release date: | 1994-12-20 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin. Protein Sci., 3, 1994
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