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PDB: 17 results

8CTG
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BU of 8ctg by Molmil
Extracellular architecture of an engineered canonical Wnt signaling ternary complex
Descriptor: Frizzled-8, Low-density lipoprotein receptor-related protein 6, PALMITOLEIC ACID, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2022-05-14
Release date:2023-03-15
Last modified:2023-03-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
7RKY
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BU of 7rky by Molmil
Binding mode of US27-Gi-scFv16 in OCL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKN
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Structure of CX3CL1-US28-Gi-scFv16 in OC-state
Descriptor: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Last modified:2024-09-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7RKM
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Structure of CX3CL1-US28-Gi-scFv16 in C-state
Descriptor: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ...
Authors:Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
7JHJ
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BU of 7jhj by Molmil
Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi
Descriptor: Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ...
Authors:Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C.
Deposit date:2020-07-20
Release date:2021-07-07
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1.
Immunity, 54, 2021
7RKF
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Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ...
Authors:Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
6WW2
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BU of 6ww2 by Molmil
Structure of human Frizzled5 by fiducial-assisted cryo-EM
Descriptor: Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ...
Authors:Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
Deposit date:2020-05-07
Release date:2020-08-19
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
Elife, 9, 2020
7RKX
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BU of 7rkx by Molmil
Structure of US27-Gi-scFv16 in CL-state
Descriptor: Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-07-22
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
8G04
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BU of 8g04 by Molmil
Structure of signaling thrombopoietin-MPL receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ...
Authors:Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
Deposit date:2023-01-31
Release date:2023-08-30
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Cell, 186, 2023
3WO2
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BU of 3wo2 by Molmil
Crystal structure of human interleukin-18
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO4
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Crystal structure of the IL-18 signaling ternary complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
3WO3
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BU of 3wo3 by Molmil
Crystal structure of IL-18 in complex with IL-18 receptor alpha
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H.
Deposit date:2013-12-19
Release date:2014-12-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structural basis for receptor recognition of human interleukin-18
Nat Commun, 5, 2014
5WB2
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BU of 5wb2 by Molmil
US28 bound to engineered chemokine CX3CL1.35 and nanobodies
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ...
Authors:Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
6X93
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BU of 6x93 by Molmil
Interleukin-10 signaling complex with IL-10RA and IL-10RB
Descriptor: Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta
Authors:Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C.
Deposit date:2020-06-02
Release date:2021-03-17
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Science, 371, 2021
8FFE
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BU of 8ffe by Molmil
Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide
Descriptor: GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ...
Authors:Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C.
Deposit date:2022-12-08
Release date:2023-03-08
Last modified:2023-03-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination.
Proc.Natl.Acad.Sci.USA, 120, 2023
7T6F
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BU of 7t6f by Molmil
Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Descriptor: ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ...
Authors:Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C.
Deposit date:2021-12-13
Release date:2022-03-16
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Science, 376, 2022
7U7N
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BU of 7u7n by Molmil
IL-27 quaternary receptor signaling complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ...
Authors:Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C.
Deposit date:2022-03-07
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structure of the IL-27 quaternary receptor signaling complex.
Elife, 11, 2022

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PDB entries from 2024-10-30

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