2L98
| Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C | Descriptor: | CALCIUM ION, RESVERATROL, Troponin C, ... | Authors: | Sykes, B.D, Pineda-Sanabria, S.E, Robertson, I.M. | Deposit date: | 2011-02-02 | Release date: | 2011-03-30 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of trans-Resveratrol in Complex with the Cardiac Regulatory Protein Troponin C. Biochemistry, 50, 2011
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1IKM
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5W88
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5WCL
| NMR structure of the N-domain of troponin C bound to switch region of troponin I and 3-methyldiphenylamine (solvent exposed mode) | Descriptor: | 3-methyl-N-phenylaniline, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... | Authors: | Cai, F, Hwang, P.M, Sykes, B.D. | Deposit date: | 2017-06-30 | Release date: | 2017-07-19 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structures reveal details of small molecule binding to cardiac troponin. J. Mol. Cell. Cardiol., 101, 2016
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1IH0
| Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033 | Descriptor: | 5-[1-(3,4-DIMETHOXY-BENZOYL)-1,2,3,4-TETRAHYDRO-QUINOLIN-6-YL]-6-METHYL-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-ONE, CALCIUM ION, TROPONIN C, ... | Authors: | Wang, X, Li, M.X, Spyracopoulos, L, Beier, N, Chandra, M, Solaro, R.J, Sykes, B.D. | Deposit date: | 2001-04-18 | Release date: | 2001-10-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033. J.Biol.Chem., 276, 2001
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3CTN
| STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES | Descriptor: | CALCIUM ION, TROPONIN C | Authors: | Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D. | Deposit date: | 1997-05-08 | Release date: | 1998-05-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain. J.Biol.Chem., 272, 1997
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7UHA
| NMR structure of the cNTnC-cTnI chimera bound to W6 | Descriptor: | CALCIUM ION, N-(5-aminopentyl)-5-chloronaphthalene-1-sulfonamide, Troponin C, ... | Authors: | Cai, F, Kampourakis, T, Cockburn, K.T, Sykes, B.D. | Deposit date: | 2022-03-26 | Release date: | 2022-06-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7. Acs Chem.Biol., 17, 2022
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7UH9
| NMR structure of the cNTnC-cTnI chimera bound to W8 | Descriptor: | CALCIUM ION, N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide, Troponin C, ... | Authors: | Cai, F, Kampourakis, T, Cockburn, K.T, Sykes, B.D. | Deposit date: | 2022-03-26 | Release date: | 2022-06-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7. Acs Chem.Biol., 17, 2022
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1Y4E
| NMR structure of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger | Descriptor: | Sodium/hydrogen exchanger 1 | Authors: | Slepkov, E.R, Rainey, J.K, Li, X, Liu, Y, Lindhout, D.A, Sykes, B.D, Fliegel, L. | Deposit date: | 2004-11-30 | Release date: | 2005-02-01 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger. J.Biol.Chem., 280, 2005
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1ZAC
| N-DOMAIN OF TROPONIN C FROM CHICKEN SKELETAL MUSCLE, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | TROPONIN-C | Authors: | Tsuda, S, Miura, A, Gagne, S.M, Spyracopoulos, L, Sykes, B.D. | Deposit date: | 1998-04-07 | Release date: | 1998-11-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C. Biochemistry, 38, 1999
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6MV3
| NMR structure of the cNTnC-cTnI chimera bound to calcium desensitizer W7 | Descriptor: | CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE, Troponin C, ... | Authors: | Cai, F, Hwang, P.M, Sykes, B.D. | Deposit date: | 2018-10-24 | Release date: | 2018-11-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Changes Induced by the Binding of the Calcium Desensitizer W7 to Cardiac Troponin. Biochemistry, 57, 2018
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2SDF
| SOLUTION NMR STRUCTURE OF STROMAL CELL-DERIVED FACTOR-1 (SDF-1), 30 STRUCTURES | Descriptor: | STROMAL CELL-DERIVED FACTOR-1 | Authors: | Crump, M.P, Rajarathnam, K, Clark-Lewis, I, Sykes, B.D. | Deposit date: | 1998-03-07 | Release date: | 1998-06-17 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1. EMBO J., 16, 1997
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2CTN
| STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES | Descriptor: | CALCIUM ION, TROPONIN C | Authors: | Sia, S.K, Li, M.X, Spyracopoulos, L, Gagne, S.M, Liu, W, Putkey, J.A, Sykes, B.D. | Deposit date: | 1997-05-06 | Release date: | 1998-05-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain. J.Biol.Chem., 272, 1997
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2EOT
| SOLUTION STRUCTURE OF EOTAXIN, AN ENSEMBLE OF 32 NMR SOLUTION STRUCTURES | Descriptor: | EOTAXIN | Authors: | Crump, M.P, Rajarathnam, K, Kim, K.-S, Clark-Lewis, I, Sykes, B.D. | Deposit date: | 1998-06-29 | Release date: | 1998-11-11 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. J.Biol.Chem., 273, 1998
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7KAA
| NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex | Descriptor: | 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol, CALCIUM ION, Troponin C, ... | Authors: | Mercier, P, Li, M.X, Hartman, J.J, Sykes, B.D. | Deposit date: | 2020-09-30 | Release date: | 2021-03-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle. J.Med.Chem., 64, 2021
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7JGI
| NMR structure of the cNTnC-cTnI chimera bound to A7 | Descriptor: | 7-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}heptanoic acid, CALCIUM ION, Troponin C, ... | Authors: | Cai, F, Robertson, I.M, Kampourakis, T, Klein, B.A, Sykes, B.D. | Deposit date: | 2020-07-19 | Release date: | 2020-09-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers. Acs Chem.Biol., 15, 2020
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5VLN
| NMR structure of the N-domain of troponin C bound to switch region of troponin I | Descriptor: | Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle | Authors: | Cai, F, Hwang, P.M, Sykes, B.D. | Deposit date: | 2017-04-25 | Release date: | 2017-05-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structures reveal details of small molecule binding to cardiac troponin. J. Mol. Cell. Cardiol., 101, 2016
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2A93
| NMR SOLUTION STRUCTURE OF THE C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER, 40 STRUCTURES | Descriptor: | C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER | Authors: | Lavigne, P, Crump, M.P, Gagne, S.M, Hodges, R.S, Kay, C.M, Sykes, B.D. | Deposit date: | 1998-06-09 | Release date: | 1999-01-27 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. J.Mol.Biol., 281, 1998
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2AFP
| THE SOLUTION STRUCTURE OF TYPE II ANTIFREEZE PROTEIN REVEALS A NEW MEMBER OF THE LECTIN FAMILY | Descriptor: | PROTEIN (SEA RAVEN TYPE II ANTIFREEZE PROTEIN) | Authors: | Gronwald, W, Loewen, M.C, Lix, B, Daugulis, A.J, Sonnichsen, F.D, Davies, P.L, Sykes, B.D. | Deposit date: | 1998-12-14 | Release date: | 1998-12-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of type II antifreeze protein reveals a new member of the lectin family. Biochemistry, 37, 1998
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1TNW
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1TNX
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1EQ1
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1KB7
| A COMPARISON OF NMR SOLUTION STRUCTURES OF THE RECEPTOR BINDING DOMAINS OF PSEUDOMONAS AERUGINOSA PILI STRAINS PAO, KB7, AND PAK: IMPLICATIONS FOR RECEPTOR BINDING AND SYNTHETIC VACCINE DESIGN | Descriptor: | KB7 PILIN, TRANS | Authors: | Campbell, A.P, Mcinnes, C, Hodges, R.S, Sykes, B.D. | Deposit date: | 1995-10-05 | Release date: | 1996-01-29 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design. Biochemistry, 34, 1995
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1KB8
| A COMPARISON OF NMR SOLUTION STRUCTURES OF THE RECEPTOR BINDING DOMAINS OF PSEUDOMONAS AERUGINOSA PILI STRAINS PAO, KB7, AND PAK: IMPLICATIONS FOR RECEPTOR BINDING AND SYNTHETIC VACCINE DESIGN | Descriptor: | KB7 PILIN, TRANS | Authors: | Campbell, A.P, Mcinnes, C, Hodges, R.S, Sykes, B.D. | Deposit date: | 1995-10-05 | Release date: | 1996-01-29 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design. Biochemistry, 34, 1995
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1KDE
| NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT, NMR, 22 STRUCTURES | Descriptor: | ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT | Authors: | Sonnichsen, F.D, Deluca, C.I, Davies, P.L, Sykes, B.D. | Deposit date: | 1996-07-08 | Release date: | 1997-04-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction. Structure, 4, 1996
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