7UH9
NMR structure of the cNTnC-cTnI chimera bound to W8
Summary for 7UH9
Entry DOI | 10.2210/pdb7uh9/pdb |
NMR Information | BMRB: 31005 |
Descriptor | Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle, CALCIUM ION, N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide (3 entities in total) |
Functional Keywords | cardiac troponin, calcium binding protein, ef hand, metal binding protein, calcium modulator |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 14581.10 |
Authors | Cai, F.,Kampourakis, T.,Cockburn, K.T.,Sykes, B.D. (deposition date: 2022-03-26, release date: 2022-06-15, Last modification date: 2024-05-15) |
Primary citation | Cai, F.,Kampourakis, T.,Cockburn, K.T.,Sykes, B.D. Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7. Acs Chem.Biol., 17:1495-1504, 2022 Cited by PubMed: 35649123DOI: 10.1021/acschembio.2c00126 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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