1KDE

NORTH-ATLANTIC OCEAN POUT ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT, NMR, 22 STRUCTURES

Summary for 1KDE

• Entry DOI: 10.2210/pdb1kde/pdb
• Related: 1KDF
• Descriptor: ANTIFREEZE PROTEIN TYPE III ISOFORM HPLC12 MUTANT (1 entity in total)
• Functional Keywords: ice binding protein, thermal hysteresis protein, antifreeze protein, glycoprotein
• Biological source: Macrozoarces americanus (ocean pout)
• Cellular location: Secreted: P19614
• Total number of polymer chains: 1
• Total formula weight: 7525.89

Authors

Sonnichsen, F.D.,Deluca, C.I.,Davies, P.L.,Sykes, B.D. (deposition date: 1996-07-08, release date: 1997-04-21, Last modification date: 2024-05-22)

Primary citation

Sonnichsen, F.D.,DeLuca, C.I.,Davies, P.L.,Sykes, B.D.
Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction.
Structure, 4:1325-1337, 1996

PubMed Abstract: Antifreeze proteins are found in certain fish inhabiting polar sea water. These proteins depress the freezing points of blood and body fluids below that of the surrounding sea water by binding to and inhibiting the growth of seed ice crystals. The proteins are believed to bind irreversibly to growing ice crystals in such a way as to change the curvature of the ice-water interface, leading to freezing point depression, but the mechanism of high-affinity ice binding is not yet fully understood.

PubMed: 8939756
DOI: 10.1016/S0969-2126(96)00140-2

Experimental method

SOLUTION NMR