1IH0

Structure of the C-domain of Human Cardiac Troponin C in Complex with Ca2+ Sensitizer EMD 57033

Summary for 1IH0

• Entry DOI: 10.2210/pdb1ih0/pdb
• Related: 1AJ4
• NMR Information: BMRB: 4994
• Descriptor: TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES, CALCIUM ION, 5-[1-(3,4-DIMETHOXY-BENZOYL)-1,2,3,4-TETRAHYDRO-QUINOLIN-6-YL]-6-METHYL-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-ONE (3 entities in total)
• Functional Keywords: ca2+ binding protein, ca2+ sensitizer, contractile protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 8757.69

Authors

Wang, X.,Li, M.X.,Spyracopoulos, L.,Beier, N.,Chandra, M.,Solaro, R.J.,Sykes, B.D. (deposition date: 2001-04-18, release date: 2001-10-10, Last modification date: 2022-02-23)

• Primary citation: Wang, X.,Li, M.X.,Spyracopoulos, L.,Beier, N.,Chandra, M.,Solaro, R.J.,Sykes, B.D.; Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.; J.Biol.Chem., 276:25456-25466, 2001; PubMed: 11320096; DOI: 10.1074/jbc.M102418200

Experimental method

SOLUTION NMR