7UHA

NMR structure of the cNTnC-cTnI chimera bound to W6

Summary for 7UHA

• Entry DOI: 10.2210/pdb7uha/pdb
• Related: 7UH9
• NMR Information: BMRB: 31006
• Descriptor: Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle, CALCIUM ION, N-(5-aminopentyl)-5-chloronaphthalene-1-sulfonamide (3 entities in total)
• Functional Keywords: cardiac troponin, calcium binding protein, ef hand, metal binding protein, calcium modulator
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 14553.05

Authors

Cai, F.,Kampourakis, T.,Cockburn, K.T.,Sykes, B.D. (deposition date: 2022-03-26, release date: 2022-06-15, Last modification date: 2023-06-14)

• Primary citation: Cai, F.,Kampourakis, T.,Cockburn, K.T.,Sykes, B.D.; Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7.; Acs Chem.Biol., 17:1495-1504, 2022; PubMed: 35649123; DOI: 10.1021/acschembio.2c00126

Experimental method

SOLUTION NMR