7KAA

NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex

Summary for 7KAA

• Entry DOI: 10.2210/pdb7kaa/pdb
• NMR Information: BMRB: 30801
• Descriptor: Troponin C, skeletal muscle,Troponin I, fast skeletal muscle chimera, CALCIUM ION, 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol (3 entities in total)
• Functional Keywords: activator, contractile protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 17366.98

Authors

Mercier, P.,Li, M.X.,Hartman, J.J.,Sykes, B.D. (deposition date: 2020-09-30, release date: 2021-03-24, Last modification date: 2023-06-14)

• Primary citation: Li, M.X.,Mercier, P.,Hartman, J.J.,Sykes, B.D.; Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.; J.Med.Chem., 64:3026-3034, 2021; PubMed: 33703886; DOI: 10.1021/acs.jmedchem.0c01412

Experimental method

SOLUTION NMR