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1JC2
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BU of 1jc2 by Molmil
COMPLEX OF THE C-DOMAIN OF TROPONIN C WITH RESIDUES 1-40 OF TROPONIN I
Descriptor: CALCIUM ION, TROPONIN C, SKELETAL MUSCLE
Authors:Mercier, P, Spyracopoulos, L, Sykes, B.D.
Deposit date:2001-06-07
Release date:2001-09-14
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure, dynamics, and thermodynamics of the structural domain of troponin C in complex with the regulatory peptide 1-40 of troponin I
Biochemistry, 40, 2001
1NPQ
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BU of 1npq by Molmil
structure of a rhodamine-labeled N-domain Troponin C mutant (Ca2+ saturated) in complex with skeletal Troponin I 115-131
Descriptor: CALCIUM ION, Troponin C, Troponin I
Authors:Mercier, P, Ferguson, R.E, Irving, M, Corrie, J.E.T, Trentham, D.R, Sykes, B.D.
Deposit date:2003-01-18
Release date:2003-04-29
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR Structure of a Bifunctional Rhodamine Labeled N-Domain of Troponin C Complexed with the Regulatory "Switch" Peptide from Troponin I: Implications for in Situ Fluorescence Studies in Muscle Fibers
Biochemistry, 42, 2003
2JMD
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BU of 2jmd by Molmil
Solution Structure of the Ring Domain of Human TRAF6
Descriptor: TNF receptor-associated factor 6, ZINC ION
Authors:Mercier, P, Lewis, M.J, Hau, D.D, Saltibus, L.F, Xiao, W, Spyracopoulos, L.
Deposit date:2006-11-02
Release date:2007-04-10
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Structure, interactions, and dynamics of the RING domain from human TRAF6
Protein Sci., 16, 2007
7KAA
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BU of 7kaa by Molmil
NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex
Descriptor: 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol, CALCIUM ION, Troponin C, ...
Authors:Mercier, P, Li, M.X, Hartman, J.J, Sykes, B.D.
Deposit date:2020-09-30
Release date:2021-03-24
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle.
J.Med.Chem., 64, 2021
2KGB
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BU of 2kgb by Molmil
NMR solution of the regulatory domain cardiac F77W-Troponin C in complex with the cardiac Troponin I 144-163 switch peptide
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ...
Authors:Mercier, P, Julien, O, Crane, M.L, Sykes, B.D.
Deposit date:2009-03-07
Release date:2009-03-24
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C.
Protein Sci., 18, 2009
2LWR
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BU of 2lwr by Molmil
Solution Structure of RING2 Domain from Parkin
Descriptor: SD01679p, ZINC ION
Authors:Mercier, P, Spratt, D.E, Manczyk, N, Shaw, G.S.
Deposit date:2012-08-06
Release date:2013-06-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
Nat Commun, 4, 2013
2M9Y
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BU of 2m9y by Molmil
Solution Structure of the Catalytic Domain of HHARI
Descriptor: E3 ubiquitin-protein ligase ARIH1, ZINC ION
Authors:Mercier, P, Spratt, D.E, Shaw, G.S.
Deposit date:2013-06-24
Release date:2013-11-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.
Plos One, 8, 2013
1PXQ
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BU of 1pxq by Molmil
Structure of Subtilisin A
Descriptor: Subtilisin A
Authors:Kawulka, K.E, Sprules, T, McKay, R.T, Mercier, P, Diaper, C.M, Zuber, P, Vederas, J.C.
Deposit date:2003-07-04
Release date:2004-06-22
Last modified:2011-10-05
Method:SOLUTION NMR
Cite:Structure of subtilisin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives
Biochemistry, 43, 2004
1U0I
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BU of 1u0i by Molmil
IAAL-E3/K3 heterodimer
Descriptor: IAAL-E3, IAAL-K3
Authors:Lindhout, D.A, Litowski, J.R, Mercier, P, Hodges, R.S, Sykes, B.D.
Deposit date:2004-07-13
Release date:2004-10-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR solution structure of a highly stable de novo heterodimeric coiled-coil
Biopolymers, 75, 2004
5TR5
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BU of 5tr5 by Molmil
Solution structure of Serine 65 phosphorylated UBL domain from parkin
Descriptor: E3 ubiquitin-protein ligase parkin
Authors:Aguirre, J.D, Dunkerley, K.M, Mercier, P, Shaw, G.S.
Deposit date:2016-10-25
Release date:2016-12-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5C1Z
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BU of 5c1z by Molmil
Parkin (UblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
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BU of 5c23 by Molmil
Parkin (S65DUblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:Kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
7JOF
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BU of 7jof by Molmil
Calcium-bound C2A Domain from Human Dysferlin
Descriptor: CALCIUM ION, Isoform 6 of Dysferlin
Authors:Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S.
Deposit date:2020-08-06
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
7K6B
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BU of 7k6b by Molmil
Solution Structure of the Dysferlin C2A Domain in its Calcium-free State
Descriptor: Isoform 15 of Dysferlin
Authors:Wang, Y, Mercier, P, Santamaria, L, Shaw, G.S.
Deposit date:2020-09-19
Release date:2021-01-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
7KRB
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BU of 7krb by Molmil
Solution Structure of the Dysferlin C2A Domain in its Calcium-bound State
Descriptor: Isoform 15 of Dysferlin
Authors:Wang, Y, Mercier, P, Santamaria, L, Shaw, G.S.
Deposit date:2020-11-19
Release date:2021-01-27
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
2JTZ
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BU of 2jtz by Molmil
Solution structure and chemical shift assignments of the F104-to-5-flurotryptophan mutant of cardiac troponin C
Descriptor: Troponin C, slow skeletal and cardiac muscles
Authors:Wang, X, Mercier, P, Letourneau, P, Sykes, B.D.
Deposit date:2007-08-10
Release date:2007-08-28
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies
Protein Sci., 14, 2005
2JT8
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BU of 2jt8 by Molmil
Solution structure of the F153-to-5-flurotryptophan mutant of human cardiac troponin C
Descriptor: Troponin C, slow skeletal and cardiac muscles
Authors:Wang, X, Mercier, P, Letourneau, P, Sykes, B.D.
Deposit date:2007-07-20
Release date:2007-08-07
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies
Protein Sci., 14, 2005
2JT3
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BU of 2jt3 by Molmil
Solution Structure of F153W cardiac troponin C
Descriptor: Troponin C
Authors:Wang, X, Mercier, P, Letourneau, P, Sykes, B.D.
Deposit date:2007-07-18
Release date:2007-07-31
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies.
Protein Sci., 14, 2005
2JT0
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BU of 2jt0 by Molmil
Solution structure of F104W cardiac troponin C
Descriptor: Troponin C, slow skeletal and cardiac muscles
Authors:Wang, X, Mercier, P, Letourneau, P.-J, Sykes, B.D.
Deposit date:2007-07-17
Release date:2008-05-27
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies.
Protein Sci., 14, 2005
2M48
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BU of 2m48 by Molmil
Solution Structure of IBR-RING2 Tandem Domain from Parkin
Descriptor: E3 UBIQUITIN-PROTEIN LIGASE PARKIN, ZINC ION
Authors:Noh, Y.J, Mercier, P, Spratt, D.E, Shaw, G.S.
Deposit date:2013-01-30
Release date:2013-05-15
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.
Nat Commun, 4, 2013
2MLE
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BU of 2mle by Molmil
NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles
Authors:Robertson, I.M, Baryshnikova, O.K, Mercier, P, Sykes, B.D.
Deposit date:2014-02-26
Release date:2014-03-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.
Biochemistry, 47, 2008
2MLF
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BU of 2mlf by Molmil
NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I
Descriptor: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles
Authors:Baryshnikova, O.K, Robertson, I.M, Mercier, P, Sykes, B.D.
Deposit date:2014-02-26
Release date:2014-03-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.
Biochemistry, 47, 2008
2N5W
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BU of 2n5w by Molmil
The NMR solution structure of octyl-tridecaptin A1 in DPC micelles
Descriptor: Octyl-tridecaptin A1
Authors:Cochrane, S.A, Findlay, B, Bakhtiary, A, Acedo, J.Z, Rodriguez-Lopez, E.M, Vederas, J.C.
Deposit date:2015-08-01
Release date:2016-09-28
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II.
Proc.Natl.Acad.Sci.USA, 113, 2016
2N5Y
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BU of 2n5y by Molmil
Solution NMR structure of octyl-tridecaptin A1 in DPC micelles containing Gram-negative lipid II
Descriptor: Octyl-tridecaptin A1
Authors:Cochrane, S.A, Findlay, B, Bakhtiary, A, Rodriguez-Lopez, E.M, Vederas, J.C.
Deposit date:2015-08-03
Release date:2016-09-28
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II.
Proc.Natl.Acad.Sci.USA, 113, 2016

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