2KGB

NMR solution of the regulatory domain cardiac F77W-Troponin C in complex with the cardiac Troponin I 144-163 switch peptide

Summary for 2KGB

• Entry DOI: 10.2210/pdb2kgb/pdb
• Related: 1AP4
• Descriptor: Troponin C, slow skeletal and cardiac muscles, Troponin I, cardiac muscle, CALCIUM ION (3 entities in total)
• Functional Keywords: troponin c, troponin i, switch peptide, cntnc, tni144-163, tfe, acetylation, calcium, cardiomyopathy, disease mutation, muscle protein, polymorphism, actin-binding, phosphoprotein, contractile protein-ca binding protein complex, contractile protein/ca binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 12369.12

Authors

Mercier, P.,Julien, O.,Crane, M.L.,Sykes, B.D. (deposition date: 2009-03-07, release date: 2009-03-24, Last modification date: 2021-10-20)

• Primary citation: Julien, O.,Mercier, P.,Crane, M.L.,Sykes, B.D.; The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C.; Protein Sci., 18:1165-1174, 2009; PubMed: 19472326; DOI: 10.1002/pro.121

Experimental method

SOLUTION NMR