2MLF

NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I

Summary for 2MLF

• Entry DOI: 10.2210/pdb2mlf/pdb
• Related: 2MLE
• NMR Information: BMRB: 19817
• Descriptor: Troponin C, slow skeletal and cardiac muscles, CALCIUM ION (2 entities in total)
• Functional Keywords: troponin c, metal binding protein, dilated cardiomyopathy, g159d, ef-hand
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 8507.40

Authors

Baryshnikova, O.K.,Robertson, I.M.,Mercier, P.,Sykes, B.D. (deposition date: 2014-02-26, release date: 2014-03-12, Last modification date: 2023-06-14)

• Primary citation: Baryshnikova, O.K.,Robertson, I.M.,Mercier, P.,Sykes, B.D.; The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.; Biochemistry, 47:10950-10960, 2008; PubMed: 18803402; DOI: 10.1021/bi801165c

Experimental method

SOLUTION NMR