2MLF

NMR structure of the dilated cardiomyopathy mutation G159D in troponin C bound to the anchoring region of troponin I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C	Troponin C, slow skeletal and cardiac muscles	polymer	72	8427.2	1	UniProt (P63316) Pfam (PF13499) In PDB	Homo sapiens (human)	TN-C
2	C	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

C: 91 - 161 (UniProt: P63316)

PDB	External Database	Details
Met 90	-	initiating methionine
Asp 159	Gly 159	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	8427.2
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	8507.4

*Water molecules are not included.