7KAA
NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Troponin C, skeletal muscle,Troponin I, fast skeletal muscle chimera | polymer | 152 | 17096.6 | 1 | UniProt (P02585) UniProt (P48788) Pfam (PF13499) Pfam (PF00992) In PDB | Homo sapiens (Human) | Troponin I,fast-twitch isoform |
2 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
3 | A | 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol | non-polymer | 230.3 | 1 | Chemie (W97) |
Sequence modifications
A: 4 - 91 (UniProt: P02585)
A: 97 - 146 (UniProt: P48788)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Ala 2 | - | expression tag |
Ser 3 | - | expression tag |
Gly 92 | - | linker |
Gly 93 | - | linker |
Ala 94 | - | linker |
Gly 95 | - | linker |
Gly 96 | - | linker |
PDB | External Database | Details |
---|---|---|
His 147 | - | expression tag |
His 148 | - | expression tag |
His 149 | - | expression tag |
His 150 | - | expression tag |
His 151 | - | expression tag |
His 152 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 17096.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 270.3 | |
All* | Total formula weight | 17367.0 |