7JGI

NMR structure of the cNTnC-cTnI chimera bound to A7

Summary for 7JGI

• Entry DOI: 10.2210/pdb7jgi/pdb
• NMR Information: BMRB: 30774
• Descriptor: Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera, CALCIUM ION, 7-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}heptanoic acid (3 entities in total)
• Functional Keywords: cardiac troponin, calcium binding protein, ef hand, metal binding protein, calcium modulator
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 14596.07

Authors

Cai, F.,Robertson, I.M.,Kampourakis, T.,Klein, B.A.,Sykes, B.D. (deposition date: 2020-07-19, release date: 2020-09-02, Last modification date: 2023-06-14)

• Primary citation: Cai, F.,Robertson, I.M.,Kampourakis, T.,Klein, B.A.,Sykes, B.D.; The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers.; Acs Chem.Biol., 15:2289-2298, 2020; PubMed: 32633482; DOI: 10.1021/acschembio.0c00519

Experimental method

SOLUTION NMR