5WYJ
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![BU of 5wyj by Molmil](/molmil-images/mine/5wyj) | Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1) | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 40S ribosomal protein S1-A, ... | Authors: | Ye, K, Zhu, X, Sun, Q. | Deposit date: | 2017-01-13 | Release date: | 2017-03-29 | Last modified: | 2019-10-09 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | Molecular architecture of the 90S small subunit pre-ribosome. Elife, 6, 2017
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7YTL
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![BU of 7ytl by Molmil](/molmil-images/mine/7ytl) | Structure of a oxidoreductase in complex with quinone | Descriptor: | Apoptosis inducing factor mitochondria associated 2, FLAVIN-ADENINE DINUCLEOTIDE, UBIQUINONE-1 | Authors: | Lv, Y, Sun, Q, Wang, Q, Zhu, D. | Deposit date: | 2022-08-15 | Release date: | 2023-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structural insights into FSP1 catalysis and ferroptosis inhibition. Nat Commun, 14, 2023
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6P9E
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![BU of 6p9e by Molmil](/molmil-images/mine/6p9e) | Crystal structure of IL-36gamma complexed to A-552 | Descriptor: | (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma | Authors: | Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E. | Deposit date: | 2019-06-10 | Release date: | 2019-06-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9, 2019
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7UAD
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![BU of 7uad by Molmil](/molmil-images/mine/7uad) | Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | Descriptor: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | Authors: | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | Deposit date: | 2022-03-12 | Release date: | 2023-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.044 Å) | Cite: | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
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3BUN
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![BU of 3bun by Molmil](/molmil-images/mine/3bun) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4 | Descriptor: | 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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3BUX
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![BU of 3bux by Molmil](/molmil-images/mine/3bux) | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in c-Met | Descriptor: | 13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL | Authors: | Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J. | Deposit date: | 2008-01-03 | Release date: | 2008-02-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27, 2008
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1R0E
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![BU of 1r0e by Molmil](/molmil-images/mine/1r0e) | Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor | Descriptor: | 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, CITRATE ANION, Glycogen synthase kinase-3 beta | Authors: | Allard, J, Nikolcheva, T, Gong, L, Wang, J, Dunten, P, Avnur, Z, Waters, R, Sun, Q, Skinner, B. | Deposit date: | 2003-09-20 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | From genetics to therapeutics: the Wnt pathway and osteoporosis To be Published
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8HQ4
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![BU of 8hq4 by Molmil](/molmil-images/mine/8hq4) | B27 in complex with CRM1-Ran-RanBP1 | Descriptor: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | Authors: | Lei, Y, Sun, Q. | Deposit date: | 2022-12-13 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | B27 in complex with CRM1-Ran-RanBP1 To Be Published
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5WYH
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![BU of 5wyh by Molmil](/molmil-images/mine/5wyh) | Crystal structure of RidL(1-200) complexed with VPS29 | Descriptor: | GLYCEROL, Interaptin, Vacuolar protein sorting-associated protein 29 | Authors: | Yao, J, Sun, Q, Jia, D. | Deposit date: | 2017-01-13 | Release date: | 2018-01-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Mechanism of inhibition of retromer transport by the bacterial effector RidL. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4GIW
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![BU of 4giw by Molmil](/molmil-images/mine/4giw) | |
3SAZ
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![BU of 3saz by Molmil](/molmil-images/mine/3saz) | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(3-bromophenyl)-2,4-dioxobutanoic acid inhibitor | Descriptor: | 4-(3-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | Authors: | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2011-06-03 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3SB0
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![BU of 3sb0 by Molmil](/molmil-images/mine/3sb0) | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid inhibitor | Descriptor: | 4-(2-chloro-6-fluoro-3-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | Authors: | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2011-06-03 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.199 Å) | Cite: | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3S9I
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![BU of 3s9i by Molmil](/molmil-images/mine/3s9i) | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 2-4-dioxo-4-phenylbutanoic acid inhibitor | Descriptor: | 2-4-DIOXO-4-PHENYLBUTANOIC ACID, MAGNESIUM ION, Malate synthase G | Authors: | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2011-06-01 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3SAD
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![BU of 3sad by Molmil](/molmil-images/mine/3sad) | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor | Descriptor: | 4-(2-methylphenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | Authors: | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2011-06-02 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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3S9Z
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![BU of 3s9z by Molmil](/molmil-images/mine/3s9z) | Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-bromophenyl)-2,4-dioxobutanoic acid inhibitor | Descriptor: | 4-(2-bromophenyl)-2,4-dioxobutanoic acid, MAGNESIUM ION, Malate synthase G | Authors: | Krieger, I.V, Sun, Q, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2011-06-02 | Release date: | 2012-11-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.793 Å) | Cite: | Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem.Biol., 19, 2012
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4NYI
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![BU of 4nyi by Molmil](/molmil-images/mine/4nyi) | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | Descriptor: | GTPase HRas, MAGNESIUM ION, N-{1-[(5-methyl-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamide, ... | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | Deposit date: | 2013-12-10 | Release date: | 2014-03-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9612 Å) | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OWX
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![BU of 4owx by Molmil](/molmil-images/mine/4owx) | Structural basis of SOSS1 in complex with a 12nt ssDNA | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1 | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | Deposit date: | 2014-02-04 | Release date: | 2014-04-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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4OWT
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![BU of 4owt by Molmil](/molmil-images/mine/4owt) | Structural basis of SOSS1 complex assembly | Descriptor: | Integrator complex subunit 3, SOSS complex subunit B1, SOSS complex subunit C | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | Deposit date: | 2014-02-03 | Release date: | 2014-04-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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4NYM
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![BU of 4nym by Molmil](/molmil-images/mine/4nym) | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | Descriptor: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]-L-tryptophanamide, ... | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | Deposit date: | 2013-12-10 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5529 Å) | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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4OWW
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![BU of 4oww by Molmil](/molmil-images/mine/4oww) | Structural basis of SOSS1 in complex with a 35nt ssDNA | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), Integrator complex subunit 3, SOSS complex subunit B1, ... | Authors: | Ren, W, Sun, Q, Tang, X, Song, H. | Deposit date: | 2014-02-04 | Release date: | 2014-04-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA. Cell Rep, 6, 2014
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8K4F
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![BU of 8k4f by Molmil](/molmil-images/mine/8k4f) | DHODH in complex with compound A0 | Descriptor: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ... | Authors: | Jian, L, Sun, Q. | Deposit date: | 2023-07-18 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66, 2023
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4NYJ
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![BU of 4nyj by Molmil](/molmil-images/mine/4nyj) | Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange | Descriptor: | GTPase HRas, MAGNESIUM ION, N-[1-(1H-indol-3-ylmethyl)piperidin-4-yl]glycinamide, ... | Authors: | Burns, M.C, Sun, Q, Phan, J, Fesik, S.W. | Deposit date: | 2013-12-10 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8522 Å) | Cite: | Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Proc.Natl.Acad.Sci.USA, 111, 2014
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6JLH
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![BU of 6jlh by Molmil](/molmil-images/mine/6jlh) | Structure of SCGN in complex with a Snap25 peptide | Descriptor: | CALCIUM ION, CHLORIDE ION, Secretagogin, ... | Authors: | Qin, J, Sun, Q, Jia, D. | Deposit date: | 2019-03-05 | Release date: | 2020-03-11 | Last modified: | 2020-04-08 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Structural and mechanistic insights into secretagogin-mediated exocytosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KN1
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![BU of 6kn1 by Molmil](/molmil-images/mine/6kn1) | P20/P12 of caspase-11 mutant C254A | Descriptor: | Caspase-4 | Authors: | Ding, J, Sun, Q. | Deposit date: | 2019-08-02 | Release date: | 2020-03-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell, 180, 2020
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6KN0
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![BU of 6kn0 by Molmil](/molmil-images/mine/6kn0) | |