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3SAD

Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 4-(2-mehtylphenyl)-2,4-dioxobutanoic acid inhibitor

Summary for 3SAD
Entry DOI10.2210/pdb3sad/pdb
Related1N8I 1N8W 2GQ3 3S9I 3S9Z 3SAZ 3SB0
DescriptorMalate synthase G, MAGNESIUM ION, 4-(2-methylphenyl)-2,4-dioxobutanoic acid, ... (4 entities in total)
Functional Keywordsinhibitor complex, structural genomics, mycobacterium tuberculosis structural proteomics project, xmtb, malate synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total formula weight80735.84
Authors
Krieger, I.V.,Sun, Q.,Sacchettini, J.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (deposition date: 2011-06-02, release date: 2012-11-07, Last modification date: 2023-09-13)
Primary citationKrieger, I.V.,Freundlich, J.S.,Gawandi, V.B.,Roberts, J.P.,Gawandi, V.B.,Sun, Q.,Owen, J.L.,Fraile, M.T.,Huss, S.I.,Lavandera, J.L.,Ioerger, T.R.,Sacchettini, J.C.
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.
Chem.Biol., 19:1556-1567, 2012
Cited by
PubMed: 23261599
DOI: 10.1016/j.chembiol.2012.09.018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

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