5KNN
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4XOI
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![BU of 4xoi by Molmil](/molmil-images/mine/4xoi) | Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution | Descriptor: | Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sun, L, Guan, R, Lee, I.-J, Liu, Y, Chen, M, Wang, J, Wu, J, Chen, Z. | Deposit date: | 2015-01-16 | Release date: | 2015-07-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Mechanistic insights into the anchorage of the contractile ring by anillin and mid1 Dev.Cell, 33, 2015
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7RWF
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![BU of 7rwf by Molmil](/molmil-images/mine/7rwf) | Crystal structure of CDK2 in complex with TW8672 | Descriptor: | 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-08-19 | Release date: | 2022-08-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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7SA0
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![BU of 7sa0 by Molmil](/molmil-images/mine/7sa0) | Crystal structure of CDK2 liganded with compound EF4195 | Descriptor: | 1,2-ETHANEDIOL, 2-{[(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-09-21 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2) To Be Published
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7S9X
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![BU of 7s9x by Molmil](/molmil-images/mine/7s9x) | Crystal structure of CDK2 liganded with compound WN378 | Descriptor: | 2-[(9H-carbazol-3-yl)amino]-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-09-21 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2) To Be Published
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7S84
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![BU of 7s84 by Molmil](/molmil-images/mine/7s84) | Crystal structure of CDK2 liganded with compound TW8972 | Descriptor: | 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-09-17 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. Nat Commun, 14, 2023
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3V0T
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![BU of 3v0t by Molmil](/molmil-images/mine/3v0t) | Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Perakine Reductase | Authors: | Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J. | Deposit date: | 2011-12-08 | Release date: | 2012-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.333 Å) | Cite: | Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. J.Biol.Chem., 287, 2012
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3V0S
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![BU of 3v0s by Molmil](/molmil-images/mine/3v0s) | Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding | Descriptor: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Perakine reductase | Authors: | Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J. | Deposit date: | 2011-12-08 | Release date: | 2012-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.773 Å) | Cite: | Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. J.Biol.Chem., 287, 2012
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3UYI
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![BU of 3uyi by Molmil](/molmil-images/mine/3uyi) | Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding | Descriptor: | Perakine reductase | Authors: | Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J. | Deposit date: | 2011-12-06 | Release date: | 2012-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.313 Å) | Cite: | Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. J.Biol.Chem., 287, 2012
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1P5J
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![BU of 1p5j by Molmil](/molmil-images/mine/1p5j) | Crystal Structure Analysis of Human Serine Dehydratase | Descriptor: | L-serine dehydratase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Sun, L, Liu, Y, Rao, Z. | Deposit date: | 2003-04-27 | Release date: | 2004-06-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Crystallogr.,Sect.D, 59, 2003
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5T76
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![BU of 5t76 by Molmil](/molmil-images/mine/5t76) | A fragment of a human tRNA synthetase | Descriptor: | Alanine--tRNA ligase, cytoplasmic | Authors: | Sun, L, Schimmel, P. | Deposit date: | 2016-09-02 | Release date: | 2016-11-30 | Last modified: | 2017-01-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5T5S
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![BU of 5t5s by Molmil](/molmil-images/mine/5t5s) | A fragment of a human tRNA synthetase | Descriptor: | Alanine--tRNA ligase, cytoplasmic | Authors: | Sun, L, Schimmel, P. | Deposit date: | 2016-08-31 | Release date: | 2016-11-30 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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8GQ6
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![BU of 8gq6 by Molmil](/molmil-images/mine/8gq6) | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | Authors: | Sun, L, Chen, Z, Hu, Y, Mao, Q. | Deposit date: | 2022-08-29 | Release date: | 2023-09-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2. Nat.Struct.Mol.Biol., 31, 2024
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3JA7
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![BU of 3ja7 by Molmil](/molmil-images/mine/3ja7) | Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution | Descriptor: | Portal protein gp20 | Authors: | Sun, L, Zhang, X, Gao, S, Rao, P.A, Padilla-Sanchez, V, Chen, Z, Sun, S, Xiang, Y, Subramaniam, S, Rao, V.B, Rossmann, M.G. | Deposit date: | 2015-04-21 | Release date: | 2015-07-22 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nat Commun, 6, 2015
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7MPH
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![BU of 7mph by Molmil](/molmil-images/mine/7mph) | GRB2 SH2 Domain with Compound 7 | Descriptor: | (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, Growth factor receptor-bound protein 2, ... | Authors: | Sun, L, Schonbrunn, E. | Deposit date: | 2021-05-04 | Release date: | 2021-09-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51, 2021
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3UA3
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![BU of 3ua3 by Molmil](/molmil-images/mine/3ua3) | Crystal Structure of Protein Arginine Methyltransferase PRMT5 in complex with SAH | Descriptor: | Protein arginine N-methyltransferase 5, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | Deposit date: | 2011-10-20 | Release date: | 2011-12-14 | Last modified: | 2011-12-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA, 108, 2011
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3UA4
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![BU of 3ua4 by Molmil](/molmil-images/mine/3ua4) | Crystal Structure of Protein Arginine Methyltransferase PRMT5 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 5 | Authors: | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | Deposit date: | 2011-10-21 | Release date: | 2011-12-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA, 108, 2011
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8J2G
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![BU of 8j2g by Molmil](/molmil-images/mine/8j2g) | Human ZnT1-D47N/D255N mutant | Descriptor: | Proton-coupled zinc antiporter SLC30A1 | Authors: | Sun, L, Liu, X, Sun, C, He, B. | Deposit date: | 2023-04-14 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the human ZnT1-D47N/D255N double mutant To Be Published
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7Y9V
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![BU of 7y9v by Molmil](/molmil-images/mine/7y9v) | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state | Descriptor: | 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 1, nanobody | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | Deposit date: | 2022-06-26 | Release date: | 2022-09-07 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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7Y9U
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![BU of 7y9u by Molmil](/molmil-images/mine/7y9u) | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the NPA-bound state | Descriptor: | 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 1, nanobody | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | Deposit date: | 2022-06-26 | Release date: | 2022-09-07 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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7Y9T
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![BU of 7y9t by Molmil](/molmil-images/mine/7y9t) | Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the apo state | Descriptor: | Auxin efflux carrier component 1, nanobody | Authors: | Sun, L, Liu, X, Yang, Z, Xia, J. | Deposit date: | 2022-06-26 | Release date: | 2022-09-07 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022
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4JPP
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![BU of 4jpp by Molmil](/molmil-images/mine/4jpp) | Bacteriophage phiX174 H protein residues 143-282 | Descriptor: | Minor spike protein H | Authors: | Sun, L, Young, L.N, Boudko, S.B, Fokine, A, Zhang, X, Rossmann, M.G, Fane, B.A. | Deposit date: | 2013-03-19 | Release date: | 2013-12-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection. Nature, 505, 2014
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4JPN
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![BU of 4jpn by Molmil](/molmil-images/mine/4jpn) | Bacteriophage phiX174 H protein residues 143-221 | Descriptor: | Minor spike protein H | Authors: | Sun, L, Young, L.N, Boudko, S.B, Fokine, A, Zhang, X, Rossmann, M.G, Fane, B.A. | Deposit date: | 2013-03-19 | Release date: | 2013-12-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection. Nature, 505, 2014
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6LYP
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![BU of 6lyp by Molmil](/molmil-images/mine/6lyp) | Cryo-EM structure of AtMSL1 wild type | Descriptor: | Mechanosensitive ion channel protein 1, mitochondrial | Authors: | Sun, L. | Deposit date: | 2020-02-15 | Release date: | 2020-04-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural Insights into a Plant Mechanosensitive Ion Channel MSL1. Cell Rep, 30, 2020
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6IJZ
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![BU of 6ijz by Molmil](/molmil-images/mine/6ijz) | Structure of a plant cation channel | Descriptor: | Calcium permeable stress-gated cation channel 1 | Authors: | Sun, L, Wang, J, Liu, X. | Deposit date: | 2018-10-12 | Release date: | 2018-12-12 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2. Nat Commun, 9, 2018
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