7MPH

GRB2 SH2 Domain with Compound 7

Summary for 7MPH

Entry DOI	10.2210/pdb7mph/pdb
Descriptor	Growth factor receptor-bound protein 2, (4-{(10R,11E,14S,18S)-18-(2-amino-2-oxoethyl)-14-[(naphthalen-1-yl)methyl]-8,17,20-trioxo-7,16,19-triazaspiro[5.14]icos-11-en-10-yl}phenyl)acetic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	inhibitor, complex, growth factor receptor, ras-mapk signaling cascade, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	71830.90
Authors	Sun, L.,Schonbrunn, E. (deposition date: 2021-05-04, release date: 2021-09-22, Last modification date: 2023-10-18)
Primary citation	Xiao, T.,Sun, L.,Zhang, M.,Li, Z.,Haura, E.B.,Schonbrunn, E.,Ji, H. Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg.Med.Chem.Lett., 51:128354-128354, 2021 Cited by PubMed: 34506932 DOI: 10.1016/j.bmcl.2021.128354 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation