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PDB: 147 件
1G02
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Ribonuclease T1 V16S mutant
分子名称: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, GUANYL-SPECIFIC RIBONUCLEASE T1
著者De Vos, S, Loris, R, Steyaert, J.
登録日2000-10-05
公開日2000-10-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Hydrophobic core manipulations in ribonuclease T1.
Biochemistry, 40, 2001
2HOH
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RIBONUCLEASE T1 (N9A MUTANT) COMPLEXED WITH 2'GMP
分子名称: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PHOSPHATE ION, ...
著者Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J.
登録日1998-09-14
公開日1998-09-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
2FF1
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Crystal structure of Trypanosoma vivax nucleoside hydrolase soaked with ImmucillinH
分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, CALCIUM ION, IAG-nucleoside hydrolase
著者Versees, W, Barlow, J, Steyaert, J.
登録日2005-12-18
公開日2006-05-23
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T.vivax: Enzyme Conformational Changes and Implications for Catalysis.
J.Mol.Biol., 359, 2006
3CFI
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Nanobody-aided structure determination of the EPSI:EPSJ pseudopilin heterdimer from Vibrio Vulnificus
分子名称: CHLORIDE ION, Nanobody NBEPSIJ_11, Type II secretory pathway, ...
著者Lam, A.Y, Pardon, E, Korotkov, K.V, Steyaert, J, Hol, W.G.J.
登録日2008-03-03
公開日2009-01-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus.
J.Struct.Biol., 166, 2009
3BU4
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RIBONUCLEASE T1 COMPLEX WITH 2'GMP
分子名称: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1)
著者Loris, R, Devos, S, Langhorst, U, Decanniere, K, Bouckaert, J, Maes, D, Transue, T.R, Steyaert, J.
登録日1998-09-14
公開日1998-09-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Conserved water molecules in a large family of microbial ribonucleases.
Proteins, 36, 1999
8BE8
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Crystal structure of SOS1-HRas-peptidomimetic4
分子名称: FORMIC ACID, GTPase HRas, SOS1-HRas-peptidomimetic4, ...
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE9
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Crystal structure of SOS1-HRas-peptidomimetic5
分子名称: CHLORIDE ION, FORMIC ACID, GTPase HRas, ...
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
3EPW
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Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
分子名称: 7-(((2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, CALCIUM ION, IAG-nucleoside hydrolase, ...
著者Versees, W, Goeminne, A, Berg, M, Vandemeulebroucke, A, Haemers, A, Augustyns, K, Steyaert, J.
登録日2008-09-30
公開日2009-03-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
Biochim.Biophys.Acta, 1794, 2009
8P7W
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Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2
分子名称: 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ATP-binding cassette sub-family G member 2, ...
著者Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
登録日2023-05-31
公開日2023-08-30
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
8P8J
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Structure of 5D3-Fab and nanobody(Nb96)-bound ABCG2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
著者Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
登録日2023-06-01
公開日2023-08-30
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
8P8A
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Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
著者Irobalieva, R.N, Manolaridis, I, Jackson, S.M, Ni, D, Pardon, E, Stahlberg, H, Steyaert, J, Locher, K.P.
登録日2023-05-31
公開日2023-08-30
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.
J.Mol.Biol., 435, 2023
4BIR
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BU of 4bir by Molmil
RIBONUCLEASE T1: FREE HIS92GLN MUTANT
分子名称: CALCIUM ION, GUANYL-SPECIFIC RIBONUCLEASE T1
著者Doumen, J, Steyaert, J.
登録日1998-01-13
公開日1998-07-15
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of histidine-40 in ribonuclease T1 catalysis: three-dimensionalstructures of the partially active His40Lys mutant.
Biochemistry, 31, 1992
3HOH
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RIBONUCLEASE T1 (THR93GLN MUTANT) COMPLEXED WITH 2'GMP
分子名称: CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1)
著者Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J.
登録日1998-09-11
公開日1998-09-16
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
3EZJ
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BU of 3ezj by Molmil
Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody
分子名称: CHLORIDE ION, General secretion pathway protein GspD, NANOBODY NBGSPD_7, ...
著者Korotkov, K.V, Pardon, E, Steyaert, J, Hol, W.G.
登録日2008-10-22
公開日2009-02-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.
Structure, 17, 2009
3K74
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Disruption of protein dynamics by an allosteric effector antibody
分子名称: Dihydrofolate reductase, Nanobody
著者Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J.
登録日2009-10-12
公開日2010-10-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
J.Mol.Biol., 407, 2011
3EPX
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BU of 3epx by Molmil
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidin-3,4-diol
分子名称: (2R,3R,4S)-2-(hydroxymethyl)-1-(quinolin-8-ylmethyl)pyrrolidine-3,4-diol, CALCIUM ION, GLYCEROL, ...
著者Versees, W, Goeminne, A, Berg, M, Vandemeulebroucke, A, Haemers, A, Augustyns, K, Steyaert, J.
登録日2008-09-30
公開日2009-03-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
Biochim.Biophys.Acta, 1794, 2009
8BE6
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Crystal structure of SOS1-HRas-peptidomimetic2
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic2, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.89880252 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE7
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Crystal structure of SOS1-HRas-peptidomimetic3
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic3, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BEA
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Crystal structure of SOS1-HRas-peptidomimetic10
分子名称: GTPase HRas, SOS1-HRas-peptidomimetic10, Son of sevenless homolog 1
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-04-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
2X1P
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Gelsolin Nanobody
分子名称: GELSOLIN NANOBODY
著者Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
登録日2010-01-03
公開日2011-01-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
2X1Q
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Gelsolin Nanobody
分子名称: GELSOLIN NANOBODY
著者Van Den Abbeele, A, Declercq, S, De Ganck, A, De Corte, V, Van Loo, B, Srinivasan, V, Steyaert, J, Van De Kerckhove, J, Gettemans, J.
登録日2010-01-03
公開日2011-01-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.06 Å)
主引用文献A Llama-Derived Gelsolin Single-Domain Antibody Blocks Gelsolin-G-Actin Interaction.
Cell.Mol.Life Sci., 67, 2010
8BE3
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Crystal structure of KRasG12V-Nanobody84
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
著者Fischer, B, Wohlkonig, A, Steyaert, J.
登録日2022-10-21
公開日2023-11-01
最終更新日2024-08-14
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
2X6M
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Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein
分子名称: ALPHA-SYNUCLEIN PEPTIDE, HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY
著者DeGenst, E, Guilliams, T, Wellens, J, O'Day, E.M, Waudby, C.A, Meehan, S, Dumoulin, M, Hsu, S.-T.D, Cremades, N, Verschueren, K.H.G, Pardon, E, Wyns, L, Steyaert, J, Christodoulou, J, Dobson, C.M.
登録日2010-02-18
公開日2010-06-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.
J.Mol.Biol., 402, 2010
3FZ0
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Inosine-Guanosine Nucleoside Hydrolase (IG-NH)
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Nucleoside hydrolase, ...
著者Vandemeulebroucke, A, Minici, C, Bruno, I, Muzzolini, L, Tornaghi, P, Parkin, D.W, Schramm, V.L, Versees, W, Steyaert, J, Degano, M.
登録日2009-01-23
公開日2010-01-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and mechanism of the 6-oxopurine nucleosidase from Trypanosoma brucei brucei
Biochemistry, 49, 2010
2YPW
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Atomic model for the N-terminus of TraO fitted in the full-length structure of the bacterial pKM101 type IV secretion system core complex
分子名称: TRAO
著者Rivera-Calzada, A, Fronzes, R, Savva, C.G, Chandran, V, Lian, P.W, Laeremans, T, Pardon, E, Steyaert, J, Remaut, H, Waksman, G, Orlova, E.V.
登録日2012-11-02
公開日2013-04-03
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (12.4 Å)
主引用文献Structure of a Bacterial Type Iv Secretion Core Complex at Subnanometre Resolution.
Embo J., 32, 2013

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