8P7W

Structure of 5D3-Fab and nanobody(Nb8)-bound ABCG2

Summary for 8P7W

• Entry DOI: 10.2210/pdb8p7w/pdb
• EMDB information: 17537
• Descriptor: ATP-binding cassette sub-family G member 2, Nanobody, 5D3(Fab) heavy chain variable domain, ... (4 entities in total)
• Functional Keywords: membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 266610.72

Authors

Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P. (deposition date: 2023-05-31, release date: 2023-08-30, Last modification date: 2023-09-13)

• Primary citation: Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P.; Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies.; J.Mol.Biol., 435:168234-168234, 2023; PubMed: 37597690; DOI: 10.1016/j.jmb.2023.168234

Experimental method

ELECTRON MICROSCOPY (3.04 Å)