3EPW
Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
Summary for 3EPW
Entry DOI | 10.2210/pdb3epw/pdb |
Related | 1HOZ 1HP0 1KIC 2FF2 3B9G 3EPX |
Descriptor | IAG-nucleoside hydrolase, CALCIUM ION, 7-(((2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, ... (5 entities in total) |
Functional Keywords | rossmann fold, active site loops, aromatic stacking, hydrolase |
Biological source | Trypanosoma vivax |
Total number of polymer chains | 2 |
Total formula weight | 75933.06 |
Authors | Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. (deposition date: 2008-09-30, release date: 2009-03-24, Last modification date: 2023-09-06) |
Primary citation | Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochim.Biophys.Acta, 1794:953-960, 2009 Cited by PubMed: 19281874DOI: 10.1016/j.bbapap.2009.02.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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