3EPW

Crystal structure of Trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2R,3R,4S)-1-[(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol

Summary for 3EPW

Entry DOI	10.2210/pdb3epw/pdb
Related	1HOZ 1HP0 1KIC 2FF2 3B9G 3EPX
Descriptor	IAG-nucleoside hydrolase, CALCIUM ION, 7-(((2R,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one, ... (5 entities in total)
Functional Keywords	rossmann fold, active site loops, aromatic stacking, hydrolase
Biological source	Trypanosoma vivax
Total number of polymer chains	2
Total formula weight	75933.06
Authors	Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. (deposition date: 2008-09-30, release date: 2009-03-24, Last modification date: 2023-09-06)
Primary citation	Versees, W.,Goeminne, A.,Berg, M.,Vandemeulebroucke, A.,Haemers, A.,Augustyns, K.,Steyaert, J. Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochim.Biophys.Acta, 1794:953-960, 2009 Cited by PubMed: 19281874 DOI: 10.1016/j.bbapap.2009.02.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation