8P8A

Structure of 5D3-Fab and nanobody(Nb17)-bound ABCG2

Summary for 8P8A

Entry DOI	10.2210/pdb8p8a/pdb
EMDB information	17543
Descriptor	5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, Nanobody, ... (5 entities in total)
Functional Keywords	membrane protein
Biological source	Mus musculus More
Total number of polymer chains	7
Total formula weight	241210.57
Authors	Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P. (deposition date: 2023-05-31, release date: 2023-08-30, Last modification date: 2023-09-13)
Primary citation	Irobalieva, R.N.,Manolaridis, I.,Jackson, S.M.,Ni, D.,Pardon, E.,Stahlberg, H.,Steyaert, J.,Locher, K.P. Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies. J.Mol.Biol., 435:168234-168234, 2023 Cited by PubMed: 37597690 DOI: 10.1016/j.jmb.2023.168234 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation