1TZG
 
 | | Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41 | | 分子名称: | Envelope polyprotein GP160, Fab 4E10, GLYCEROL | | 著者 | Cardoso, R.M.F, Zwick, M.B, Stanfield, R.L, Kunert, R, Binley, J.M, Katinger, H, Burton, D.R, Wilson, I.A. | | 登録日 | 2004-07-09 | | 公開日 | 2005-03-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41
Immunity, 22, 2005
|
|
4F6N
 | | Crystal structure of Kaiso zinc finger DNA binding protein in complex with methylated CpG site DNA | | 分子名称: | DNA (5'-D(*CP*GP*TP*AP*TP*AP*GP*AP*(5CM)P*GP*(5CM)P*GP*GP*TP*GP*AP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*TP*CP*AP*CP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*AP*TP*AP*CP*G)-3'), GLYCEROL, ... | | 著者 | Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E. | | 登録日 | 2012-05-15 | | 公開日 | 2012-09-05 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4F6M
 | | Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA | | 分子名称: | DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), Transcriptional regulator Kaiso, ... | | 著者 | Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E. | | 登録日 | 2012-05-15 | | 公開日 | 2012-09-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
6X1S
 | | Structure of pHis Fab (SC1-1) in complex with pHis mimetic peptide | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, NM23-1-pTza peptide, SC1-1 Heavy chain, ... | | 著者 | Kalagiri, R, Stanfield, R.L, Wilson, I.A, Hunter, T. | | 登録日 | 2020-05-19 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
2OQJ
 | | Crystal structure analysis of Fab 2G12 in complex with peptide 2G12.1 | | 分子名称: | Fab 2G12 heavy chain, Fab 2G12 light chain, peptide 2G12.1 (ACPPSHVLDMRSGTCLAAEGK) | | 著者 | Calarese, D.A, Stanfield, R.L, Menendez, A, Scott, J.K, Wilson, I.A. | | 登録日 | 2007-01-31 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120.
Faseb J., 22, 2008
|
|
6X1T
 | | Structure of pHis Fab (SC50-3) in complex with pHis mimetic peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kalagiri, R, Stanfield, R.L, Wilson, I.A, Hunter, T. | | 登録日 | 2020-05-19 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Structural basis for differential recognition of phosphohistidine-containing peptides by 1-pHis and 3-pHis monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
5C7K
 | | Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 8ANC195 heavy chain, ... | | 著者 | Kong, L, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2015-06-24 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (4.6019 Å) | | 主引用文献 | Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer.
Acta Crystallogr.,Sect.D, 71, 2015
|
|
7LVS
 | | The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide | | 分子名称: | Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone lysine acetyltransferase CREBBP, ZINC ION | | 著者 | Appling, F.D, Berlow, R.B, Stanfield, R.L, Dyson, H.J, Wright, P.E. | | 登録日 | 2021-02-26 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | The molecular basis of allostery in a facilitated dissociation process.
Structure, 29, 2021
|
|
2QSC
 | | Crystal structure analysis of anti-HIV-1 V3-Fab F425-B4e8 in complex with a V3-peptide | | 分子名称: | CHLORIDE ION, Envelope glycoprotein gp120, Fab F425-B4e8, ... | | 著者 | Bell, C.H, Schiefner, A, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2007-07-30 | | 公開日 | 2008-01-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.
J.Mol.Biol., 375, 2008
|
|
8T5X
 | | Probing the dissociation pathway of a kinetically labile transthyretin mutant (A25T) | | 分子名称: | Transthyretin | | 著者 | Ferguson, J.A, Sun, X, Leach, B.I, Stanfield, R.L, Dyson, H.J, Wright, P.E. | | 登録日 | 2023-06-14 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Probing the Dissociation Pathway of a Kinetically Labile Transthyretin Mutant.
J.Am.Chem.Soc., 146, 2024
|
|
7JPI
 | | Crystal structure of EBOV glycoprotein with modified HR2 stalk at 2.3A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, ... | | 著者 | Chaudhary, A, Stanfield, R.L, Wilson, I.A, Zhu, J. | | 登録日 | 2020-08-08 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines.
Nat Commun, 12, 2021
|
|
8W1N
 | |
8W2W
 | |
1TCR
 | | MURINE T-CELL ANTIGEN RECEPTOR 2C CLONE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Garcia, K.C, Degano, M, Stanfield, R.L, Wilson, I.A. | | 登録日 | 1996-09-12 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.
Science, 274, 1996
|
|
6V8U
 | | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a modified Kaiso binding sequence (KBS) | | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*CP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*GP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | | 著者 | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | | 登録日 | 2019-12-12 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | | 主引用文献 | A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.
Biochemistry, 59, 2020
|
|
6UNA
 | | Crystal structure of inactive p38gamma | | 分子名称: | GLYCEROL, Mitogen-activated protein kinase 12, SULFATE ION | | 著者 | Aoto, P.C, Stanfield, R.L, Wilson, I.A, Dyson, H.J, Wright, P.E. | | 登録日 | 2019-10-11 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | | 主引用文献 | A Dynamic Switch in Inactive p38 gamma Leads to an Excited State on the Pathway to an Active Kinase.
Biochemistry, 58, 2019
|
|
6O30
 | | Lipid A transporter MsbA from Salmonella typhimurium | | 分子名称: | Lipid A export ATP-binding/permease protein MsbA | | 著者 | Padayatti, P.S, Zhang, Q, Wilson, I.A, Lee, S.C, Stanfield, R.L. | | 登録日 | 2019-02-25 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (4.47 Å) | | 主引用文献 | Structural Insights into the Lipid A Transport Pathway in MsbA.
Structure, 27, 2019
|
|
6MG4
 | | Structure of full-length human lambda-6A light chain JTO | | 分子名称: | JTO light chain | | 著者 | Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W. | | 登録日 | 2018-09-12 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
6MG5
 | | Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1 | | 分子名称: | 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, Light chain JTO, PHOSPHATE ION | | 著者 | Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W. | | 登録日 | 2018-09-12 | | 公開日 | 2019-04-10 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
5W6D
 | | Crystal structure of BG505-SOSIP.v4.1-GT1-N137A in complex with Fabs 35022 and 9H/109L | | 分子名称: | 109L FAB light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Garces, F, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2017-06-16 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.202 Å) | | 主引用文献 | Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
J. Exp. Med., 214, 2017
|
|
3TYG
 | | Crystal structure of broad and potent HIV-1 neutralizing antibody PGT128 in complex with a glycosylated engineered gp120 outer domain with miniV3 (eODmV3) | | 分子名称: | Envelope glycoprotein gp160, PGT128 heavy chain, Ig gamma-1 chain C region, ... | | 著者 | Pejchal, R, Huang, P.S, Schief, W.R, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2011-09-25 | | 公開日 | 2011-10-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science, 334, 2011
|
|
7U5G
 | | ACS122 Fab | | 分子名称: | ACS122 Fab Heavy chain, ACS122 Fab Light chain | | 著者 | Farokhi, E, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2022-03-02 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer.
Plos Pathog., 18, 2022
|
|
6N2X
 | | Anti-HIV-1 Fab 2G12 + Man9 re-refinement | | 分子名称: | Fab 2G12 heavy chain, Fab 2G12 light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Calarese, D.A, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2018-11-14 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science, 300, 2003
|
|
6N35
 | | Anti-HIV-1 Fab 2G12 + Man1-2 re-refinement | | 分子名称: | BENZOIC ACID, Fab 2G12 heavy chain, Fab 2G12 light chain, ... | | 著者 | Calarese, D.A, Stanfield, R.L, Wilson, I.A. | | 登録日 | 2018-11-14 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.747 Å) | | 主引用文献 | Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science, 300, 2003
|
|
6N32
 | |
