6V8U

Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a modified Kaiso binding sequence (KBS)

Summary for 6V8U

• Entry DOI: 10.2210/pdb6v8u/pdb
• Related: 6DF5 6DF8 6DF9 6DFA 6DFB 6DFC
• Descriptor: Transcriptional regulator Kaiso, DNA (5'-D(*TP*GP*CP*TP*TP*CP*GP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*CP*GP*AP*AP*GP*CP*A)-3'), ... (7 entities in total)
• Functional Keywords: dna methylation, zinc finger, transcriptional regulator, dna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 27504.61

Authors

Nikolova, E.N.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E. (deposition date: 2019-12-12, release date: 2020-04-15, Last modification date: 2023-10-11)

• Primary citation: Nikolova, E.N.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E.; A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.; Biochemistry, 59:1909-1926, 2020; PubMed: 32352758; DOI: 10.1021/acs.biochem.0c00253

Experimental method

X-RAY DIFFRACTION (2.103 Å)