1TZG

Crystal structure of HIV-1 neutralizing human Fab 4E10 in complex with a 13-residue peptide containing the 4E10 epitope on gp41

Summary for 1TZG

• Entry DOI: 10.2210/pdb1tzg/pdb
• Descriptor: Fab 4E10, Envelope polyprotein GP160, GLYCEROL, ... (5 entities in total)
• Functional Keywords: antibody-epitope complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 99018.40

Authors

Cardoso, R.M.F.,Zwick, M.B.,Stanfield, R.L.,Kunert, R.,Binley, J.M.,Katinger, H.,Burton, D.R.,Wilson, I.A. (deposition date: 2004-07-09, release date: 2005-03-01, Last modification date: 2023-08-23)

• Primary citation: Cardoso, R.M.F.,Zwick, M.B.,Stanfield, R.L.,Kunert, R.,Binley, J.M.,Katinger, H.,Burton, D.R.,Wilson, I.A.; Broadly Neutralizing Anti-HIV Antibody 4E10 Recognizes a Helical Conformation of a Highly Conserved Fusion-Associated Motif in gp41; Immunity, 22:163-173, 2005; PubMed: 15723805; DOI: 10.1016/j.immuni.2004.12.011

Experimental method

X-RAY DIFFRACTION (2.2 Å)