6MG5

Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1

Summary for 6MG5

Entry DOI	10.2210/pdb6mg5/pdb
Descriptor	Light chain JTO, PHOSPHATE ION, 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, ... (4 entities in total)
Functional Keywords	light chain, amyloidosis, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	47280.87
Authors	Morgan, G.J.,Yan, N.L.,Mortenson, D.E.,Stanfield, R.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2018-09-12, release date: 2019-04-10, Last modification date: 2019-12-25)
Primary citation	Morgan, G.J.,Yan, N.L.,Mortenson, D.E.,Rennella, E.,Blundon, J.M.,Gwin, R.M.,Lin, C.Y.,Stanfield, R.L.,Brown, S.J.,Rosen, H.,Spicer, T.P.,Fernandez-Vega, V.,Merlini, G.,Kay, L.E.,Wilson, I.A.,Kelly, J.W. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proc.Natl.Acad.Sci.USA, 116:8360-8369, 2019 Cited by PubMed: 30971495 DOI: 10.1073/pnas.1817567116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation