5E6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e6s by Molmil](/molmil-images/mine/5e6s) | Structures of leukocyte integrin aLB2: The aI domain, the headpiece, and the pocket for the internal ligand | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Integrin alpha-L, ... | Authors: | Springer, T.A, Sen, M. | Deposit date: | 2015-10-10 | Release date: | 2016-03-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
2VDP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdp by Molmil](/molmil-images/mine/2vdp) | Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide,LGGAKQAGDV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdk by Molmil](/molmil-images/mine/2vdk) | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdo by Molmil](/molmil-images/mine/2vdo) | Integrin AlphaIIbBeta3 Headpiece Bound to Fibrinogen Gamma chain peptide, HHLGGAKQAGDV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdn by Molmil](/molmil-images/mine/2vdn) | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, EPTIFIBATIDE, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdm by Molmil](/molmil-images/mine/2vdm) | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Tirofiban | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdl by Molmil](/molmil-images/mine/2vdl) | Re-refinement of Integrin AlphaIIbBeta3 Headpiece | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CACODYLATE ION, CALCIUM ION, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdr by Molmil](/molmil-images/mine/2vdr) | Integrin AlphaIIbBeta3 Headpiece Bound to a chimeric Fibrinogen Gamma chain peptide, LGGAKQRGDV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VDQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vdq by Molmil](/molmil-images/mine/2vdq) | Integrin AlphaIIbBeta3 Headpiece Bound to a Chimeric Fibrinogen Gamma chain peptide, HHLGGAKQRGDV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-10-10 | Release date: | 2008-09-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
2VC2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vc2 by Molmil](/molmil-images/mine/2vc2) | Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758 | Descriptor: | 2-(S)-[N-(3-PYRIDYLSULFONYL)AMINO]-3-[[2-CARBONYL-5-[2-(PIPERIDIN-4-YL)ETHYL]-THIENO[2,3-B]THIOPHENEYL]AMINO]-PROPIONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Springer, T.A, Zhu, J, Xiao, T. | Deposit date: | 2007-09-18 | Release date: | 2008-09-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3. J.Cell Biol., 182, 2008
|
|
4G1M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4g1m by Molmil](/molmil-images/mine/4g1m) | Re-refinement of alpha V beta 3 structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Springer, T.A, Mi, L, Zhu, J. | Deposit date: | 2012-07-10 | Release date: | 2012-12-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications Biochemistry, 51, 2012
|
|
5E6X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e6x by Molmil](/molmil-images/mine/5e6x) | |
5E6W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e6w by Molmil](/molmil-images/mine/5e6w) | |
4HBQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hbq by Molmil](/molmil-images/mine/4hbq) | Crystal structure of a loop deleted mutant of Human MAdCAM-1 D1D2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Mucosal addressin cell adhesion molecule 1, ... | Authors: | Springer, T, Yu, Y, Zhu, J. | Deposit date: | 2012-09-28 | Release date: | 2013-01-23 | Last modified: | 2021-05-26 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | A Different Fold with an Integrin-Binding Loop Specialized for Flexibility in Mucosal Addressin Cell Adhesion Molecule-1 TO BE PUBLISHED
|
|
4HC1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hc1 by Molmil](/molmil-images/mine/4hc1) | |
4HCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hcr by Molmil](/molmil-images/mine/4hcr) | |
4HD9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hd9 by Molmil](/molmil-images/mine/4hd9) | Crystal structure of native human MAdCAM-1 D1D2 domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucosal addressin cell adhesion molecule 1 | Authors: | Springer, T, Yu, Y, Zhu, J. | Deposit date: | 2012-10-02 | Release date: | 2013-01-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Different Fold with an Integrin-Binding Loop Specialized for Flexibility in Mucosal Addressin Cell Adhesion Molecule-1 TO BE PUBLISHED
|
|
1T0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t0p by Molmil](/molmil-images/mine/1t0p) | Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-L, Intercellular adhesion molecule-3, ... | Authors: | Song, G, Yang, Y.T, Liu, J.H, Shimaoko, M, Springer, T.A, Wang, J.H. | Deposit date: | 2004-04-12 | Release date: | 2005-03-08 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
8FXV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fxv by Molmil](/molmil-images/mine/8fxv) | Crystal structure of human proTGF-beta2 in complex with Nb18 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 18, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8FXS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fxs by Molmil](/molmil-images/mine/8fxs) | Crystal structure of human pro-TGF-beta2 in complex with Nb9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 9, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4IRZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4irz by Molmil](/molmil-images/mine/4irz) | Crystal structure of A4b7 headpiece complexed with Fab Natalizumab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yu, Y, Schurpf, T, Springer, T.A. | Deposit date: | 2013-01-15 | Release date: | 2013-09-25 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | How natalizumab binds and antagonizes alpha 4 integrins. J.Biol.Chem., 288, 2013
|
|
5VQF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vqf by Molmil](/molmil-images/mine/5vqf) | Crystal Structure of pro-TGF-beta 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. | Deposit date: | 2017-05-08 | Release date: | 2017-11-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
|
|
7S0K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7s0k by Molmil](/molmil-images/mine/7s0k) | HAP2 from Cyanidioschyzon merolae | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Feng, J, Dong, X.C, Springer, T.A. | Deposit date: | 2021-08-30 | Release date: | 2022-07-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state. Nat Commun, 13, 2022
|
|
3ZDY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zdy by Molmil](/molmil-images/mine/3zdy) | Integrin alphaIIB beta3 headpiece and RGD peptide complex | Descriptor: | 10E5 FAB HEAVY CHAIN, 10E5 FAB LIGHT CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhu, J.H, Zhu, J.Q, Springer, T.A. | Deposit date: | 2012-12-03 | Release date: | 2013-06-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Complete Integrin Headpiece Opening in Eight Steps. J.Cell Biol., 201, 2013
|
|
3ZE2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ze2 by Molmil](/molmil-images/mine/3ze2) | Integrin alphaIIB beta3 headpiece and RGD peptide complex | Descriptor: | 10E5 FAB HEAVY CHAIN, 10E5 FAB LIGHT CHAIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhu, J.H, Zhu, J.Q, Springer, T.A. | Deposit date: | 2012-12-03 | Release date: | 2013-06-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Complete Integrin Headpiece Opening in Eight Steps. J.Cell Biol., 201, 2013
|
|