2VC2

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist L-739758

Replaces:  1TY7

Summary for 2VC2

Related1MK7 2VDQ 1M8O 1S4X 2VDN 1UV9 1TYE 1S4W 1MK9 1M1X 1RN0 1L5G 2VDM 1DPQ 2VDO 2VDP 1JV2 1DPK 2VDR 2VDK 1KUP 1KUZ 2VDL 1MIZ 1U8C 1JX5
DescriptorINTEGRIN ALPHA-IIB, INTEGRIN BETA-3, MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN, ... (11 entities in total)
Functional Keywordscell adhesion-immune system complex, fibrinogen binding, host-virus interaction, pyrrolidone carboxylic acid, transmembrane, cell adhesion/immune system
Biological sourceHOMO SAPIENS (HUMAN)
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Total number of polymer chains4
Total molecular weight151084.82
Authors
Springer, T.A.,Zhu, J.,Xiao, T. (deposition date: 2007-09-18, release date: 2008-09-02, Last modification date: 2019-02-06)
Primary citation
Springer, T.A.,Zhu, J.,Xiao, T.
Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.
J.Cell Biol., 182:791-, 2008
PubMed: 18710925 (PDB entries with the same primary citation)
DOI: 10.1083/JCB.200801146
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2244 0.3% 1.2% 2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2vc2
no rotation
Molmil generated image of 2vc2
rotated about x axis by 90°
Molmil generated image of 2vc2
rotated about y axis by 90°