7Z06
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6H23
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![BU of 6h23 by Molmil](/molmil-images/mine/6h23) | Crystal structure of the hClpP Y118A mutant with an activating small molecule | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, mitochondrial, ... | 著者 | Kick, L.M, Sieber, S.A, Schneider, S. | 登録日 | 2018-07-13 | 公開日 | 2018-08-29 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.089 Å) | 主引用文献 | Selective Activation of Human Caseinolytic Protease P (ClpP). Angew. Chem. Int. Ed. Engl., 57, 2018
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8OLL
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![BU of 8oll by Molmil](/molmil-images/mine/8oll) | Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.7 A resolution | 分子名称: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-03-30 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8OLR
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![BU of 8olr by Molmil](/molmil-images/mine/8olr) | Structure of yeast 20S proteasome in complex with the natural product beta-lactone inhibitor Cystargolide A | 分子名称: | CHLORIDE ION, Cystargolide A (bound), MAGNESIUM ION, ... | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-03-30 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R05
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![BU of 8r05 by Molmil](/molmil-images/mine/8r05) | Photorhabdus lamondii ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.5 A resolution | 分子名称: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-10-30 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R03
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![BU of 8r03 by Molmil](/molmil-images/mine/8r03) | Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution | 分子名称: | 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-10-30 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R04
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![BU of 8r04 by Molmil](/molmil-images/mine/8r04) | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A | 分子名称: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-10-30 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8CRL
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![BU of 8crl by Molmil](/molmil-images/mine/8crl) | Crystal structure of LplA1 in complex with the inhibitor C3 (Listeria monocytogenes) | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, SODIUM ION, ... | 著者 | Dienemann, J.-N, Chen, S.-Y, Hitzenberger, M, Sievert, M.L, Hacker, S.M, Prigge, S.T, Zacharias, M, Groll, M, Sieber, S.A. | 登録日 | 2023-03-08 | 公開日 | 2023-06-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angew.Chem.Int.Ed.Engl., 62, 2023
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8CRI
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![BU of 8cri by Molmil](/molmil-images/mine/8cri) | Crystal structure of LplA1 in complex with lipoic acid (Listeria monocytogenes) | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, LIPOIC ACID, ... | 著者 | Dienemann, J.-N, Chen, S.-Y, Hitzenberger, M, Sievert, M.L, Hacker, S.M, Prigge, S.T, Zacharias, M, Groll, M, Sieber, S.A. | 登録日 | 2023-03-08 | 公開日 | 2023-06-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angew.Chem.Int.Ed.Engl., 62, 2023
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8CRJ
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![BU of 8crj by Molmil](/molmil-images/mine/8crj) | Crystal structure of LplA1 in complex with lipoyl-AMP (Listeria monocytogenes) | 分子名称: | 1,2-ETHANEDIOL, 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, GLYCEROL, ... | 著者 | Dienemann, J.-N, Chen, S.-Y, Hitzenberger, M, Sievert, M.L, Hacker, S.M, Prigge, S.T, Zacharias, M, Groll, M, Sieber, S.A. | 登録日 | 2023-03-08 | 公開日 | 2023-06-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angew.Chem.Int.Ed.Engl., 62, 2023
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3QWD
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![BU of 3qwd by Molmil](/molmil-images/mine/3qwd) | Crystal structure of ClpP from Staphylococcus aureus | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | 著者 | Geiger, S.R, Boettcher, T, Sieber, S.A, Cramer, P. | 登録日 | 2011-02-28 | 公開日 | 2011-05-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Conformational Switch Underlies ClpP Protease Function. Angew.Chem.Int.Ed.Engl., 50, 2011
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4LQI
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![BU of 4lqi by Molmil](/molmil-images/mine/4lqi) | Yeast 20S Proteasome in complex with Vibralactone | 分子名称: | Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ... | 著者 | List, A, Zeiler, E, Gallastegui, N, Rusch, M, Hedberg, C, Sieber, S.A, Groll, M. | 登録日 | 2013-07-18 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences. Angew.Chem.Int.Ed.Engl., 53, 2014
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4MXI
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![BU of 4mxi by Molmil](/molmil-images/mine/4mxi) | ClpP Ser98dhA | 分子名称: | ATP-dependent Clp protease proteolytic subunit | 著者 | Gersch, M, Kolb, R, Alte, F, Groll, M, Sieber, S.A. | 登録日 | 2013-09-26 | 公開日 | 2013-10-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition. J.Am.Chem.Soc., 136, 2014
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2M0G
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![BU of 2m0g by Molmil](/molmil-images/mine/2m0g) | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition | 分子名称: | Splicing factor 1, Splicing factor U2AF 65 kDa subunit | 著者 | Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. | 登録日 | 2012-10-25 | 公開日 | 2013-01-30 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
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2M09
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![BU of 2m09 by Molmil](/molmil-images/mine/2m09) | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition | 分子名称: | Splicing factor 1 | 著者 | Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. | 登録日 | 2012-10-22 | 公開日 | 2013-01-30 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
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4R17
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![BU of 4r17 by Molmil](/molmil-images/mine/4r17) | Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome | 分子名称: | (2S,3S)-3-methylaziridine-2-carboxylic acid, MAGNESIUM ION, Proteasome subunit alpha type-1, ... | 著者 | Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M. | 登録日 | 2014-08-04 | 公開日 | 2014-10-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angew.Chem.Int.Ed.Engl., 53, 2014
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4R18
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![BU of 4r18 by Molmil](/molmil-images/mine/4r18) | Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome | 分子名称: | ALPHA-AMINOBUTYRIC ACID, MAGNESIUM ION, PROTEASOME SUBUNIT ALPHA TYPE-1, ... | 著者 | Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M. | 登録日 | 2014-08-04 | 公開日 | 2014-10-15 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angew.Chem.Int.Ed.Engl., 53, 2014
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4RYF
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![BU of 4ryf by Molmil](/molmil-images/mine/4ryf) | ClpP1/2 heterocomplex from Listeria monocytogenes | 分子名称: | ATP-dependent Clp protease proteolytic subunit, MALONATE ION, SODIUM ION | 著者 | Dahmen, M, Vielberg, M.-T, Groll, M, Sieber, S.A. | 登録日 | 2014-12-15 | 公開日 | 2014-12-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes. Angew.Chem.Int.Ed.Engl., 54, 2015
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4C5N
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![BU of 4c5n by Molmil](/molmil-images/mine/4c5n) | Structure of the pyridoxal kinase from Staphylococcus aureus in complex with AMP-PCP and pyridoxal | 分子名称: | 3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYLISONICOTINALDEHYDE, 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Nodwell, M, Alte, F, Sieber, S.A, Schneider, S. | 登録日 | 2013-09-12 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage. J.Am.Chem.Soc., 136, 2014
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4C5M
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![BU of 4c5m by Molmil](/molmil-images/mine/4c5m) | Structure of the pyridoxal kinase from Staphylococcus aureus in complex with AMP-PCP | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION | 著者 | Nodwell, M, Alte, F, Sieber, S.A, Schneider, S. | 登録日 | 2013-09-12 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage. J.Am.Chem.Soc., 136, 2014
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4C5K
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![BU of 4c5k by Molmil](/molmil-images/mine/4c5k) | Structure of the pyridoxal kinase from Staphylococcus aureus in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION | 著者 | Nodwell, M, Alte, F, Sieber, S.A, Schneider, S. | 登録日 | 2013-09-12 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage. J.Am.Chem.Soc., 136, 2014
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4C5J
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![BU of 4c5j by Molmil](/molmil-images/mine/4c5j) | Structure of the pyridoxal kinase from Staphylococcus aureus | 分子名称: | PHOSPHOMETHYLPYRIMIDINE KINASE, SULFATE ION | 著者 | Nodwell, M, Alte, F, Sieber, S.A, Schneider, S. | 登録日 | 2013-09-12 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage. J.Am.Chem.Soc., 136, 2014
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4C5L
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![BU of 4c5l by Molmil](/molmil-images/mine/4c5l) | Structure of the pyridoxal kinase from Staphylococcus aureus in complex with pyridoxal | 分子名称: | 3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYLISONICOTINALDEHYDE, 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol, PHOSPHOMETHYLPYRIMIDINE KINASE, ... | 著者 | Nodwell, M, Alte, F, Sieber, S.A, Schneider, S. | 登録日 | 2013-09-12 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage. J.Am.Chem.Soc., 136, 2014
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5AC2
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![BU of 5ac2 by Molmil](/molmil-images/mine/5ac2) | human aldehyde dehydrogenase 1A1 with duocarmycin analog | 分子名称: | 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, RETINAL DEHYDROGENASE 1, YTTERBIUM (III) ION, ... | 著者 | Koch, M.F, Harteis, S, Blank, I.D, Pestel, G, Tietze, L.F, Ochsenfeld, C, Schneider, S, Sieber, S.A. | 登録日 | 2015-08-11 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew.Chem.Int.Ed.Engl., 54, 2015
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5AC0
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![BU of 5ac0 by Molmil](/molmil-images/mine/5ac0) | ovis aries Aldehyde Dehydrogenase 1A1 in complex with a duocarmycin analog | 分子名称: | 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Koch, M.F, Harteis, S, Blank, I.D, Pestel, G, Tietze, L.F, Ochsenfeld, C, Schneider, S, Sieber, S.A. | 登録日 | 2015-08-10 | 公開日 | 2015-08-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew.Chem.Int.Ed.Engl., 54, 2015
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