8R04

Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A

Summary for 8R04

• Entry DOI: 10.2210/pdb8r04/pdb
• Related: 3V5E
• Descriptor: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) (3 entities in total)
• Functional Keywords: anti-virulence, caseinolytic protease, inhibitor, natural product, mode of action, hydrolase
• Biological source: Aquifex aeolicus
• Total number of polymer chains: 14
• Total formula weight: 320087.26

Authors

Illigmann, A.,Vielberg, M.-T.,Lakemeyer, M.,Wolf, F.,Staudt, N.,Dema, T.,Stange, P.,Liebhart, E.,Kuttenlochner, W.,Kulik, A.,Malik, I.,Grond, S.,Sieber, S.A.,Groll, M.,Kaysser, L.,Broetz-Oesterhelt, H. (deposition date: 2023-10-30, release date: 2023-12-20, Last modification date: 2024-01-24)

• Primary citation: Illigmann, A.,Vielberg, M.T.,Lakemeyer, M.,Wolf, F.,Dema, T.,Stange, P.,Kuttenlochner, W.,Liebhart, E.,Kulik, A.,Staudt, N.D.,Malik, I.,Grond, S.,Sieber, S.A.,Kaysser, L.,Groll, M.,Brotz-Oesterhelt, H.; Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.; Angew.Chem.Int.Ed.Engl., 63:e202314028-e202314028, 2024; PubMed: 38029352; DOI: 10.1002/anie.202314028

Experimental method

X-RAY DIFFRACTION (2.1 Å)