9FCU
| CysG(N-16)-H121A mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | S-ADENOSYL-L-HOMOCYSTEINE, SAM-dependent methyltransferase | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FD3
| CysG(N-16)-D190N mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-16 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCD
| CysG(N-16) in complex with SAH from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CARBONATE ION, ... | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCQ
| CysG(N-16)-H122A mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCX
| CysG(N-16)-H121N mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, SAM-dependent methyltransferase | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-16 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9G0K
| CysG(N-16) in complex with SAH (metal free, cocrystallization in presence of EDTA) from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, SAM-dependent methyltransferase | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-07-08 | Release date: | 2024-07-17 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCY
| CysG(N-16)-R21K mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | ADENINE, CALCIUM ION, SAM-dependent methyltransferase | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-16 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCS
| CysG(N-16)-H122N mutant in complex with SAH from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, S-ADENOSYL-L-HOMOCYSTEINE, SAM-dependent methyltransferase | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCL
| CysG(N-16) in complex with SAM from Kitasatospora cystarginea | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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9FCE
| BelI in complex with SAM from Streptomyces sp. UCK14 | Descriptor: | (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Kuttenlochner, W, Beller, P, Kaysser, L, Groll, M. | Deposit date: | 2024-05-15 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure-activity relationship study. J.Biol.Chem., 300, 2024
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8OLL
| Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.7 A resolution | Descriptor: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | Authors: | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | Deposit date: | 2023-03-30 | Release date: | 2023-12-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8OLR
| Structure of yeast 20S proteasome in complex with the natural product beta-lactone inhibitor Cystargolide A | Descriptor: | CHLORIDE ION, Cystargolide A (bound), MAGNESIUM ION, ... | Authors: | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | Deposit date: | 2023-03-30 | Release date: | 2023-12-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R03
| Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution | Descriptor: | 1,2-ETHANEDIOL, ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | Authors: | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | Deposit date: | 2023-10-30 | Release date: | 2023-12-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R05
| Photorhabdus lamondii ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.5 A resolution | Descriptor: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | Authors: | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | Deposit date: | 2023-10-30 | Release date: | 2023-12-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R04
| Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A | Descriptor: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | Authors: | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | Deposit date: | 2023-10-30 | Release date: | 2023-12-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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