8OLR

Structure of yeast 20S proteasome in complex with the natural product beta-lactone inhibitor Cystargolide A

Summary for 8OLR

• Entry DOI: 10.2210/pdb8olr/pdb
• Related: 6G7F
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: anti-virulence, proteasome, inhibitor, natural product, mode of action, hydrolase
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 28
• Total formula weight: 733526.55

Authors

Illigmann, A.,Vielberg, M.-T.,Lakemeyer, M.,Wolf, F.,Staudt, N.,Dema, T.,Stange, P.,Malik, I.,Grond, S.,Sieber, S.A.,Groll, M.,Kaysser, L.,Broetz-Oesterhelt, H. (deposition date: 2023-03-30, release date: 2023-12-06, Last modification date: 2024-01-24)

• Primary citation: Illigmann, A.,Vielberg, M.T.,Lakemeyer, M.,Wolf, F.,Dema, T.,Stange, P.,Kuttenlochner, W.,Liebhart, E.,Kulik, A.,Staudt, N.D.,Malik, I.,Grond, S.,Sieber, S.A.,Kaysser, L.,Groll, M.,Brotz-Oesterhelt, H.; Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.; Angew.Chem.Int.Ed.Engl., 63:e202314028-e202314028, 2024; PubMed: 38029352; DOI: 10.1002/anie.202314028

Experimental method

X-RAY DIFFRACTION (2.8 Å)