8CRJ

Crystal structure of LplA1 in complex with lipoyl-AMP (Listeria monocytogenes)

Summary for 8CRJ

Entry DOI	10.2210/pdb8crj/pdb
Related	8CRI
Descriptor	lipoate--protein ligase, 5'-O-[(R)-({5-[(3R)-1,2-DITHIOLAN-3-YL]PENTANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	lipoate, salvage, anti-infectives, drug development, ligase
Biological source	Listeria monocytogenes
Total number of polymer chains	1
Total formula weight	40398.43
Authors	Dienemann, J.-N.,Chen, S.-Y.,Hitzenberger, M.,Sievert, M.L.,Hacker, S.M.,Prigge, S.T.,Zacharias, M.,Groll, M.,Sieber, S.A. (deposition date: 2023-03-08, release date: 2023-06-07, Last modification date: 2023-09-20)
Primary citation	Dienemann, J.N.,Chen, S.Y.,Hitzenberger, M.,Sievert, M.L.,Hacker, S.M.,Prigge, S.T.,Zacharias, M.,Groll, M.,Sieber, S.A. A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites. Angew.Chem.Int.Ed.Engl., 62:e202304533-e202304533, 2023 Cited by PubMed: 37249408 DOI: 10.1002/anie.202304533 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation