4LQI

Yeast 20S Proteasome in complex with Vibralactone

Summary for 4LQI

Related1RYP 2FAK 3E47
DescriptorProteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ... (16 entities in total)
Functional Keywordsbeta-lactone, inhibitor, natural product, target identification, ntn-protease, cellular protein degradation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSaccharomyces cerevisiae (Baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight705047.32
Authors
List, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M. (deposition date: 2013-07-18, release date: 2013-12-25, Last modification date: 2014-01-22)
Primary citation
List, A.,Zeiler, E.,Gallastegui, N.,Rusch, M.,Hedberg, C.,Sieber, S.A.,Groll, M.
Omuralide and Vibralactone: Differences in the Proteasome-beta-Lactone-gamma-Lactam Binding Scaffold Alter Target Preferences.
Angew.Chem.Int.Ed.Engl., 53:571-574, 2014
PubMed: 24285701 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201308567
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.228151.0%4.9%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4lqi
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Molmil generated image of 4lqi
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Molmil generated image of 4lqi
rotated about y axis by 90°