2FAK

Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome

Summary for 2FAK

Related1RYP 1IRU
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywordsproteasome, ubiquitin, drug design, inhibitor, protease, hydrolase
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight705882.23
Authors
Groll, M.,Potts, B.C. (deposition date: 2005-12-07, release date: 2006-04-18, Last modification date: 2011-07-13)
Primary citation
Groll, M.,Huber, R.,Potts, B.C.
Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128:5136-5141, 2006
PubMed: 16608349 (PDB entries with the same primary citation)
DOI: 10.1021/ja058320b
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253171.0%5.6%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution