5AC0
ovis aries Aldehyde Dehydrogenase 1A1 in complex with a duocarmycin analog
Summary for 5AC0
Entry DOI | 10.2210/pdb5ac0/pdb |
Related | 5ABM 5AC1 5AC2 |
Descriptor | RETINAL DEHYDROGENASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one, ... (5 entities in total) |
Functional Keywords | oxidoreductase, aldehyde dehydrogenase activity, oxidation-reduction process |
Biological source | OVIS ARIES (SHEEP) |
Cellular location | Cytoplasm: P51977 |
Total number of polymer chains | 2 |
Total formula weight | 111741.42 |
Authors | Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A. (deposition date: 2015-08-10, release date: 2015-08-26, Last modification date: 2024-01-10) |
Primary citation | Koch, M.F.,Harteis, S.,Blank, I.D.,Pestel, G.,Tietze, L.F.,Ochsenfeld, C.,Schneider, S.,Sieber, S.A. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew.Chem.Int.Ed.Engl., 54:13550-, 2015 Cited by PubMed: 26373694DOI: 10.1002/ANIE.201505749 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report