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PDB: 234 件
5HDH
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Crystal structure of human TLR8 with an uncleaved Z-loop
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2016-01-05
公開日2016-03-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
Proc.Natl.Acad.Sci.USA, 113, 2016
5IRN
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Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form1)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRM
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BU of 5irm by Molmil
Crystal structure of rabbit NOD2 in an ADP-bound state (Crystal form2)
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.31 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
5IRL
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BU of 5irl by Molmil
Crystal structure of rabbit NOD2 SER mutant in an ADP-bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, Uncharacterized protein
著者Maekawa, S, Ohto, U, Shimizu, T.
登録日2016-03-14
公開日2016-06-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Crystal structure of NOD2 and its implications in human disease.
Nat Commun, 7, 2016
8J6N
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BU of 8j6n by Molmil
Crystal structure of Cystathionine gamma-lyase in complex with compound 1
分子名称: 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ...
著者Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K.
登録日2023-04-26
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Sci Rep, 13, 2023
5XGC
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BU of 5xgc by Molmil
Crystal structure of SmgGDS-558
分子名称: Rap1 GTPase-GDP dissociation stimulator 1
著者Shimizu, H, Toma-Fukai, S, Shimizu, T.
登録日2017-04-13
公開日2017-06-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding
J. Biol. Chem., 292, 2017
1CXZ
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BU of 1cxz by Molmil
CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, PROTEIN (HIS-TAGGED TRANSFORMING PROTEIN RHOA(0-181)), ...
著者Maesaki, R, Ihara, K, Shimizu, T, Kuroda, S, Kaibuchi, K, Hakoshima, T.
登録日1999-08-31
公開日1999-10-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Mol.Cell, 4, 1999
1GD2
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BU of 1gd2 by Molmil
CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA
分子名称: DNA (5'-D(*AP*GP*GP*TP*TP*AP*CP*GP*TP*AP*AP*CP*C)-3'), TRANSCRIPTION FACTOR PAP1
著者Fujii, Y, Shimizu, T, Toda, T, Yanagida, M, Hakoshima, T.
登録日2000-08-25
公開日2000-10-02
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the diversity of DNA recognition by bZIP transcription factors.
Nat.Struct.Biol., 7, 2000
6IR4
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BU of 6ir4 by Molmil
Crystal structure of BioU from Synechocystis sp.PCC6803 (apo form)
分子名称: Slr0355 protein
著者Sakaki, K, Oishi, K, Shimizu, T, Tomita, T, Kuzuyama, T, Nishiyama, M.
登録日2018-11-10
公開日2020-01-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
Nat.Chem.Biol., 16, 2020
4QBZ
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BU of 4qbz by Molmil
Crystal structure of human TLR8 in complex with DS-802
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2014-05-09
公開日2014-10-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
4R6A
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BU of 4r6a by Molmil
Crystal structure of human TLR8 in complex with Hybrid-2
分子名称: 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2014-08-22
公開日2015-08-26
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes
To be Published
4QC0
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BU of 4qc0 by Molmil
Crystal structure of human TLR8 in complex with XG-1-236
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2014-05-09
公開日2014-10-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
8HRX
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BU of 8hrx by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
8HRY
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BU of 8hry by Molmil
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
分子名称: Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ...
著者Asami, J, Shimizu, T, Ohto, U.
登録日2022-12-16
公開日2024-01-17
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural basis of hepatitis B virus receptor binding.
Nat.Struct.Mol.Biol., 31, 2024
6IF5
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BU of 6if5 by Molmil
Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ...
著者Zhang, Z, Ohto, U, Shimizu, T.
登録日2018-09-18
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
5ZHX
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BU of 5zhx by Molmil
Crystal structure of SmgGDS-558 and farnesylated RhoA complex
分子名称: FARNESYL, Rap1 GTPase-GDP dissociation stimulator 1, Transforming protein RhoA
著者Shimizu, H, Toma-Fukai, S, Shimizu, T.
登録日2018-03-13
公開日2018-09-05
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1GLN
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BU of 1gln by Molmil
ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE
分子名称: GLUTAMYL-TRNA SYNTHETASE
著者Nureki, O, Vassylyev, D.G, Katayanagi, K, Shimizu, T, Sekine, S, Kigawa, T, Miyazawa, T, Yokoyama, S, Morikawa, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日1994-07-20
公開日1995-10-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Architectures of class-defining and specific domains of glutamyl-tRNA synthetase.
Science, 267, 1995
8ISN
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BU of 8isn by Molmil
HLA-A24 in complex with modified 9mer WT1 peptide
分子名称: Beta-2-microglobulin, CYS-TYR-THR-TRP-ASN-GLN-MET-ASN-LEU, GLYCEROL, ...
著者Bekker, G.J, Numoto, N, Kawasaki, M, Hayashi, T, Yabuno, S, Kozono, Y, Shimizu, T, Kozono, H, Ito, N, Oda, M, Kamiya, N.
登録日2023-03-21
公開日2023-09-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Elucidation of binding mechanism, affinity, and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02.
Protein Sci., 32, 2023
5JKC
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BU of 5jkc by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKD
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BU of 5jkd by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKE
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BU of 5jke by Molmil
Crystal structure of human IZUMO1-JUNO complex (crystal form 3)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ...
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKB
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BU of 5jkb by Molmil
Crystal structure of human JUNO (crystal form 2)
分子名称: CHLORIDE ION, Sperm-egg fusion protein Juno
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JKA
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BU of 5jka by Molmil
Crystal structure of human JUNO (crystal form 1)
分子名称: CHLORIDE ION, Sperm-egg fusion protein Juno, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
5JK9
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BU of 5jk9 by Molmil
Crystal structure of human IZUMO1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Izumo sperm-egg fusion protein 1
著者Ohto, U, Ishida, H, Shimizu, T.
登録日2016-04-26
公開日2016-06-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
1V3V
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BU of 1v3v by Molmil
Crystal structure of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complexed with NADP and 15-oxo-PGE2
分子名称: (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Hori, T, Yokomizo, T, Ago, H, Sugahara, M, Ueno, G, Yamamoto, M, Kumasaka, T, Shimizu, T, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2003-11-06
公開日2004-07-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop
J.Biol.Chem., 279, 2004

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