5HDH

Crystal structure of human TLR8 with an uncleaved Z-loop

Summary for 5HDH

Entry DOI	10.2210/pdb5hdh/pdb
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	immune system, tlr8, innate immunity, proteolytic cleavage
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	95302.10
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2016-01-05, release date: 2016-03-09, Last modification date: 2020-07-29)
Primary citation	Tanji, H.,Ohto, U.,Motoi, Y.,Shibata, T.,Miyake, K.,Shimizu, T. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8 Proc.Natl.Acad.Sci.USA, 113:3012-3017, 2016 Cited by PubMed: 26929371 DOI: 10.1073/pnas.1516000113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation