5HDH
Crystal structure of human TLR8 with an uncleaved Z-loop
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Toll-like receptor 8 | polymer | 801 | 91407.5 | 1 | UniProt (Q9NR97) Pfam (PF13855) In PDB | Homo sapiens (Human) | |
2 | B | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
4 | D | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
5 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
7 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
8 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 27 - 827 (UniProt: Q9NR97)
PDB | External Database | Details |
---|---|---|
Asn 452 | Arg 452 | engineered mutation |
Gln 453 | Lys 453 | engineered mutation |
Ser 454 | Arg 454 | engineered mutation |
Asn 455 | Arg 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 91407.5 | |
Branched | Number of molecules | 3 |
Total formula weight | 2083.9 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1810.7 | |
All* | Total formula weight | 95302.1 |