4QC0

Crystal structure of human TLR8 in complex with XG-1-236

Summary for 4QC0

• Entry DOI: 10.2210/pdb4qc0/pdb
• Related: 4QBZ
• Descriptor: Toll-like receptor 8, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: leucine rich repeat, glycosylation, innate immunity, rna recognition, ssrna, rna receptor, structure-based ligand design, tlr8 and tlr7 agonist, vaccine adjuvants, antiviral and antitumor drug binding, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 189765.69

Authors

Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2014-05-09, release date: 2014-10-22, Last modification date: 2020-07-29)

• Primary citation: Yoo, E.,Salunke, D.B.,Sil, D.,Guo, X.,Salyer, A.C.D.,Hermanson, A.R.,Kumar, M.,Malladi, S.S.,Balakrishna, R.,Thompson, W.H.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A.; Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds; J.Med.Chem., 57:7955-7970, 2014; PubMed: 25192394; DOI: 10.1021/jm500744f

Experimental method

X-RAY DIFFRACTION (2.1 Å)