Summary for 4QBZ
| Related | 4QC0 |
|---|---|
| Descriptor | Toll-like receptor 8, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... (6 entities in total) |
| Functional Keywords | leucine rich repeat, glycosylation, innate immunity, rna recognition, ssrna, rna binding, secreted, structure-based ligand design, tlr8 and tlr7 agonist, vaccine adjuvants, rna receptor, antiviral and antitumor drug binding, rna binding protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane ; Single-pass type I membrane protein Q9NR97 |
| Total number of polymer chains | 2 |
| Total molecular weight | 192502.19 |
| Authors | |
| Primary citation | Yoo, E.,Salunke, D.B.,Sil, D.,Guo, X.,Salyer, A.C.D.,Hermanson, A.R.,Kumar, M.,Malladi, S.S.,Balakrishna, R.,Thompson, W.H.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A. Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds J.Med.Chem., 57:7955-7970, 2014 PubMed: 25192394 (PDB entries with the same primary citation) DOI: 10.1021/jm500744f  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
