8H6J
| Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, W, Zhan, X, Zhang, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2022-10-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
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4O2E
| A peptide complexed with HLA-B*3901 | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-39 alpha chain, ... | 著者 | Sun, M, Liu, J, Qi, J, Tefsen, B, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2013-12-17 | 公開日 | 2014-07-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.981 Å) | 主引用文献 | N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol., 192, 2014
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4O2F
| A peptide complexed with HLA-B*3901 | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-39 alpha chain, ... | 著者 | Sun, M, Liu, J, Qi, J, Tefsen, B, Shi, Y, Yan, J, Gao, G.F. | 登録日 | 2013-12-17 | 公開日 | 2014-07-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation J.Immunol., 192, 2014
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4O79
| Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 10 minutes | 分子名称: | ASCORBIC ACID, PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, ... | 著者 | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | 登録日 | 2013-12-24 | 公開日 | 2014-02-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA, 111, 2014
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4O7G
| Crystal Structure of Ascorbate-bound Cytochrome b561, crystal soaked in 1 M L-ascorbate for 40 minutes | 分子名称: | ASCORBIC ACID, PROTOPORPHYRIN IX CONTAINING FE, Probable transmembrane ascorbate ferrireductase 2, ... | 著者 | Lu, P, Ma, D, Yan, C, Gong, X, Du, M, Shi, Y. | 登録日 | 2013-12-24 | 公開日 | 2014-02-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.211 Å) | 主引用文献 | Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase Proc.Natl.Acad.Sci.USA, 111, 2014
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4M68
| Crystal structure of the mouse MLKL kinase-like domain | 分子名称: | GLYCEROL, Mixed lineage kinase domain-like protein | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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6KUU
| Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) | 分子名称: | 3'-vRNA, 5'-vRNA, Polymerase 3, ... | 著者 | Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. | 登録日 | 2019-09-02 | 公開日 | 2019-12-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published
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6DRD
| RNA Pol II(G) | 分子名称: | DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | Yu, X, Jishage, M, Shi, Y, Ganesan, S, Sali, A, Chait, B.T, Asturias, F, Roeder, R.G. | 登録日 | 2018-06-11 | 公開日 | 2019-06-12 | 最終更新日 | 2019-12-04 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. Nat. Struct. Mol. Biol., 25, 2018
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4M66
| Crystal structure of the mouse RIP3 kinase domain | 分子名称: | Receptor-interacting serine/threonine-protein kinase 3 | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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7BCQ
| ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | 分子名称: | 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | 著者 | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | 登録日 | 2020-12-21 | 公開日 | 2021-09-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCT
| ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation. | 分子名称: | Neutral amino acid transporter B(0) | 著者 | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | 登録日 | 2020-12-21 | 公開日 | 2021-09-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7C9I
| Human gamma-secretase in complex with small molecule L-685,458 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2020-06-05 | 公開日 | 2021-01-27 | 最終更新日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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7CTT
| Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state. | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Peng, Q, Peng, R, Shi, Y. | 登録日 | 2020-08-20 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir. Innovation (N Y), 2, 2021
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7DCR
| cryo-EM structure of the DEAH-box helicase Prp2 in complex with its coactivator Spp2 | 分子名称: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2 | 著者 | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-26 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7DCQ
| cryo-EM structure of the DEAH-box helicase Prp2 | 分子名称: | PRP2 isoform 1 | 著者 | Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-26 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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7D8X
| CryoEM structure of human gamma-secretase in complex with E2012 and L685458 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y. | 登録日 | 2020-10-11 | 公開日 | 2021-01-27 | 最終更新日 | 2021-02-03 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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7DD3
| Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2 | 分子名称: | PRP2 isoform 1, Pre-mRNA-splicing factor SPP2, pre-mRNA | 著者 | Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y. | 登録日 | 2020-10-27 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2. Science, 371, 2021
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1K99
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2JXW
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1L8Z
| Solution structure of HMG box 5 in human upstream binding factor | 分子名称: | upstream binding factor 1 | 著者 | Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. | 登録日 | 2002-03-22 | 公開日 | 2002-06-05 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
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6KLD
| Structure of apo Machupo virus polymerase | 分子名称: | MANGANESE (II) ION, RNA-directed RNA polymerase L, ZINC ION | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | 登録日 | 2019-07-30 | 公開日 | 2020-03-18 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural insight into arenavirus replication machinery. Nature, 579, 2020
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6KLE
| Monomeric structure of Machupo virus polymerase bound to vRNA promoter | 分子名称: | MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ... | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | 登録日 | 2019-07-30 | 公開日 | 2020-03-18 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural insight into arenavirus replication machinery. Nature, 579, 2020
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1L8Y
| Solution structure of HMG box 5 in human upstream binding factor | 分子名称: | upstream binding factor 1 | 著者 | Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. | 登録日 | 2002-03-22 | 公開日 | 2002-06-05 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
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6KLH
| Dimeric structure of Machupo virus polymerase bound to vRNA promoter | 分子名称: | MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ... | 著者 | Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y. | 登録日 | 2019-07-30 | 公開日 | 2020-03-18 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insight into arenavirus replication machinery. Nature, 579, 2020
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1K88
| Crystal structure of procaspase-7 | 分子名称: | procaspase-7 | 著者 | Chai, J, Wu, Q, Shiozaki, E, Srinivasa, S.M, Alnemri, E.S, Shi, Y. | 登録日 | 2001-10-23 | 公開日 | 2001-11-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Cell(Cambridge,Mass.), 107, 2001
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