6KLH

Dimeric structure of Machupo virus polymerase bound to vRNA promoter

Summary for 6KLH

• Entry DOI: 10.2210/pdb6klh/pdb
• EMDB information: 0710
• Descriptor: RNA-directed RNA polymerase L, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: polymerase, rna virus, viral protein-rna complex, viral protein/rna
• Biological source: Machupo virus (MACV); More
• Total number of polymer chains: 4
• Total formula weight: 513212.12

Authors

Peng, R.,Xu, X.,Jing, J.,Peng, Q.,Gao, G.F.,Shi, Y. (deposition date: 2019-07-30, release date: 2020-03-18, Last modification date: 2021-12-08)

• Primary citation: Peng, R.,Xu, X.,Jing, J.,Wang, M.,Peng, Q.,Liu, S.,Wu, Y.,Bao, X.,Wang, P.,Qi, J.,Gao, G.F.,Shi, Y.; Structural insight into arenavirus replication machinery.; Nature, 579:615-619, 2020; PubMed: 32214249; DOI: 10.1038/s41586-020-2114-2

Experimental method

ELECTRON MICROSCOPY (3.7 Å)